Korelasi Derajat Leukoaraiosis dengan Faktor-faktor Risiko Stroke dan Keparahan Stroke Berdasarkan Derajat Klinis pada Pasien Stroke Iskemik

Yohanes Irsandy, Sri Asriyani, Bachtiar Murtala, Burhanuddin Bahar, Ashari Bahar, Nurlaily Idris

Abstract


Penelitian ini bertujuan mengetahui korelasi derajat leukoaraiosis berdasarkan CT-Scan kepala dengan faktor-faktor risiko stroke dan keparahan stroke berdasarkan derajat klinis pada pasien stroke iskemik. Metode yang digunakan adalah cross sectional, dilakukan secara retrospektif pada penderita stroke iskemik yang menjalani pemeriksaan CT-Scan kepala di Bagian Radiologi RSUP dr. Wahidin Sudirohusodo, Makassar periode Januari 2020 sampai Juli 2020. Sampel sebanyak 46 orang dengan usia >40 tahun yang mengalami serangan stroke pertama dengan onset <1 bulan. Derajat leukoaraiosis dinilai dengan menggunakan skala Van Swieten dan derajat klinis dinilai dengan menggunakan National Institute of Health Stroke Scale (NIHSS). Uji statistik yang digunakan adalah uji korelasi Spearman. Hasil penelitian menunjukkan bahwa ada korelasi bermakna yang sedang dan searah antara derajat leukoaraiosis dan kelompok umur dengan nilai p sebesar 0,004 (<0,05) dan nilai r sebesar 0,415. Tidak ada korelasi bermakna antara derajat leukoaraiosis dengan jenis kelamin, hipertensi, diabetes melitus, dislipidemia dan derajat klinis dengan nilai p masing-masing secara berurutan sebesar 0,146; 0,520; 0,779; 0,185; dan 0,537 (>0,05). Namun tampak kecenderungan bahwa pasien dengan hipertensi tidak terkontrol memiliki derajat leukoaraiosis yang lebih berat.

Keywords


Leukoaraiosis; Stroke Iskemik; Skala Van Swieten; NIHSS

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References


Arsava E.M. et al. (2009). ‘Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke’, Neurology, 72(16), pp. 1403–1410. doi: 10.1212/WNL.0b013e3181a18823.

Barker-Collo S. et al. (2015). ‘Sex differences in stroke incidence, prevalence,mortality and disability-adjusted life years: Results from the global burden of disease study 2013’, Neuroepidemiology, 45(3), pp. 203–214. doi: 10.1159/000441103.

Del Bene A. et al. (2015). ‘Is type 2 diabetes related to leukoaraiosis? an updated review’, Acta Neurologica Scandinavica, 132(3), pp. 147–155. doi: 10.1111/ane.12398.

Grueter B.E and Schulz U.G. (2012). ‘Age-related cerebral white matter disease (Leukoaraiosis): A review’, Postgraduate Medical Journal, 88(1036), pp. 79–87. doi: 10.1136/postgradmedj-2011-130307.

Helenius J and Henninger N. (2015). ‘Leukoaraiosis Burden Significantly Modulates the Association between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke’, Stroke, 46(7), pp. 1857–1863. doi: 10.1161/STROKEAHA.115.009258.

Ke D. et al. (2018). ‘Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke’, Behavioural neurology, 2018, p. 1361780. doi: 10.1155/2018/1361780.

Kuo H.K and Lipsitz L.A. (2004). ‘Cerebral white matter changes and geriatric syndromes: Is there a link?’, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 59(8), pp. 818–826. doi: 10.1093/gerona/59.8.m818.

Lyden P. (2017). ‘Using the National Institutes of Health Stroke Scale’, Stroke, 48(2), pp. 513–519. doi: 10.1161/STROKEAHA.116.015434.

Marek M. et al. (2017). ‘Leukoaraiosis and its correlation with a stroke .’

Marek M. et al. (2018). ‘Leukoaraiosis - New concepts and modern imaging’, Polish Journal of Radiology, 83, pp. e76–e81. doi: 10.5114/pjr.2018.74344.

Marek M. et al. (2019). ‘Relationship between stroke severity, extensity of leukoaraiosis, and brain atrophy in patients with ischaemic stroke’, Polish Journal of Radiology, 84, pp. e80–e85. doi: 10.5114/pjr.82917.

Ovbiagele B and Nguyen-Huynh M.N. (2011). ‘Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy’, Neurotherapeutics, 8(3), pp. 319–329. doi: 10.1007/s13311-011-0053-1.

Sacco R.L. et al. (2013). ‘An updated definition of stroke for the 21st century: A statement for healthcare professionals from the American heart association/American stroke association’, Stroke, 44(7), pp. 2064–2089. doi: 10.1161/STR.0b013e318296aeca.

Simoni M. et al. (2012). ‘Age- and sex-specific rates of leukoaraiosis in TIA and stroke patients population-based study’, Neurology, 79(12), pp. 1215–1222. doi: 10.1212/WNL.0b013e31826b951e.

Vedala K. et al. (2019). ‘Factors Associated with Leukoaraiosis Severity in Acute Stroke Patients’, Journal of Stroke and Cerebrovascular Diseases, 28(7), pp. 1897–1901. doi: 10.1016/j.jstrokecerebrovasdis.2019.04.003.

Yang K. et al. (2020). ‘Abnormal blood pressure circadian rhythms are relevant to cerebral infarction and Leukoaraiosis in hypertensive patients’, BMC Neurology, 20(1), pp. 1–10. doi: 10.1186/s12883-020-1626-6.

Zafar A. et al. (2016). ‘Risk factors and subtypes of acute ischemic stroke: A study at king fahd hospital of the university’, Neurosciences, 21(3), pp. 246–251. doi: 10.17712/nsj.2016.3.20150731.




DOI: https://doi.org/10.33476/ms.v7i2.1702

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