Efek Bubuk Susu Kedelai terhadap Kadar Kolesterol LDL dan HDL Serum Wanita Perimenopause dengan Hiperkolesterolemia

Authors

  • Retno Kuntarti
  • Sri Sukmaniah
  • Sri Widia A. Jusman

https://doi.org/10.33476/ms.v4i2.908

Keywords:

Hypercholesterolemia, Soy milk powder, LDL, HDL

Abstract

Perimenopausal women is at risk of atherosclerosis as a result of the increase of LDL cholesterol level and the decrease of HDL cholesterol level.  Soy milk powder consumption may protect toward these risk factors. This purpose of study is to investigate the effects of 2x30 g/d soy milk flour for eight weeks on serum cholesterol LDL and HDL levels in hypercholesterolemic perimenopausal women. The 19 subjects received 2x30 g/d soy milk powder for eight weeks. LDL and HDL serum cholesterol levels were determined at 0, 4, 9 weeks. Dietary intakes were assesed using 1x24 hours food recall. Statistical analysis used t Test. After eight weeks intervention, Soy milk powder decreases significant (p less than 0.05) LDL cholesterol levels at the 4tweek (8.59 plus-minus 17.31%), and the8th week (7.81 plus-minus 11.32%). Soy milk powder can’t increase HDL cholesterol levels at the 4th and 8th weeks significantly.  Soy milk decrease significant the ratio of LDL to HDL (7,03 plus-minus 16,82%) at the 4th week. Consuming soy milk powder 2 x 30 g/d during eight weeks can reduce the LDL cholesterol level and LDL/HDL ratio significantly.

References

Bassan R. Cardiovascular changes and cardiac morbidity of menopause. Effect of hormone replacement therapy. Arq Bras Cardiol 1999; 72: 92-98

Crouse JR, Morgan T, Terry JG, Ellis J, Vitollins M, Burke GL. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 1999; 159: 2070-2076

Data Statistik Indonesia. “Angka Harapan Hidup”. Diakses tanggal 3 Februari 2007 (http://www.datastatistik- indonesia.com)

Dewell A, Hollenbeck P, Hollenbeck CB.

Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentration. J Clin Endocrinol Metab 2006; 91: 772-780

Erdman JW. Soy protein and cardiovaskular disease: a statement for healthcare professionals from the nutrition committee of the AHA. Circulation 2000; 102: 2555-2559

Gultekin E dan Yildiz F. Introduction to Phytoestrogens. Dalam: Yildiz F editor. Phytoestrogen in Functional Foods. New York: Taylor & Francis Group, 2006. hal 3-18.

Hermansen K, Sondergaard M, Hoeie L, Carstensen M, Brock B. Beneficial effects of a soy based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetes subjects. Diabetes Care 2001;24: 228-233

Hu FB, Stampfer MJ, Manson JE, Ascherio A, Colditz GA, Speizer FE, Hennekens CA, Willet WC. Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 1999; 70 (6): 1001-1008

Juweni. Pengaruh suplementasi formula tempe terhadap kadar malondialdehida dan F2- isoprostan pada penderita hiperkolesterolemia. Jakarta: Tesis. Program sesudah sarjana universitas indonesia. Program studi ilmu gizi klinik, 2000

Klein NA. Endocrine chages of the perimenopause. Clinical Obstetrics and Gynecology 1998; 41, 912-920.

Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels S, Deckelbaum LJ, Erdman JW, Kris-Etherthon P, Goldberg IJ, Kotchen T, Lichtensein A. AHA dietary guidelines: revision 2000: a statement for healthcare professionals from the nutrition committee of the american heart association. Circulation 2000; 102: 2284-2299

Leverve XM. Integration of metabolism 1: energy. Dalam: Gibney MJ, Macdonald I, Roche HM eds. Nutrition and metabolism 1st ed. Iowa: Blackwell 2003; hal 30-42

Lichtensein A, Appel LJ, Brands M, Carnethon M, Daniels S, Franch AH, Franklin B, Kris-Etherthon P, Harris W, Howard B. Diet and lifestyle recommendations revision 2006: a scientific statement frpm american heart association nutrition committee. Circulation 2006; 114: 82-96

Lo GS dan Cole TG. Soy cotyledon fiber products reduces plasma lipids. Atherosclerosis 1990; 82: 59-67

Mangelsdorf DJ dan Zhang Y. Luxuries of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. Moleculer interventions 2002; 2: 78-84

Marks DB, Marks AD, Smith CM. Biokimia Kedokteran Dasar: Metabolisme kolesterol dan lipoprotein darah. Jakarta: EGC, 2000. hal. 512-544.

Mathai K. Nutrition in the adult years.

Dalam: Mahan LK, Escott- Stump S, editors. Krause’s Food Nutrition and Diet Therapy. 11th ed. USA: Saunders, 2004. Hal 302-317.

Mullen E, Brown RM, Osborne TF, Shay NF. Soy isoflavone affects sterol regulatory element binding protein (SREBPs) and SREBP- regulated enes in hepG2 cells. J Nutr 2004; 134: 2942-2947.

Nikander E, Tiitinen A, Laitinen K, Tikkanen M, Ylirkorkala O. Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women. J Clin Endocrinol Metab 2004; 89 (7): 3567 – 3572.

Raghu B dan Venkasten P. Effect of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines in humans: a pilot study. Indian Journal of clinical Biochemistry 2008; 23 (1): 85-88.

Riccardi G, Rivellese A, Williams C. The cardiovascular system. Dalam: Gibney MJ, Macdonald I, Roche HM eds. Nutrition and metabolism 1st ed. Iowa: Blackwell 2003; hal 224-246

Scaefer EJ. Lipoproteins, nutritions, and heart disease. Am J Clin Nutr 2002; 75: 191-212

Schlenker ED. Carbohydrates. Dalam: Schlenker ED, Long S eds. William’s essentials of nutrition and diet therapy 9th ed. Philadelphia: MOSBY Elsevier 2007; hal 29-45

Sugano M. Nutritional implications of soy. Dalam: Sugano M, editor. Soy in Health and Disease Prevention. New York: Taylor & Francis Group, 2006. hal 1-16.

Thorp AA, Howe PRC, Mori TA, Coates AM, Buckley JD, Hodgson J, Mansour J, Meyer BJ. Soyfood consumption does not lower LDL cholesterol in either equol or nonequol producers. Am J Clin Nutr 2008; 88 (2): 298-304

Torres N, Villalvazo IT, Tovar AR. Regulation of lipid metabolism by soy protein and its implication in disease mediated by lipid disorders. Journal of Nutritional Biochemistry 2006; 17; 6: 365-373.

Wangen KE, Duncan AM, Xu X, Kurzer MS. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J of Clin Nutr 2001; 73(2): 225-231

Welty FK. Cardiovasculer disease and dyslipidemia in women. Arch Intern Med 2001; 16: 514-522

Yayasan Jantung Indonesia. Obesitas. id.inaheart.or.id. diakses tanggal 3/11/2008

Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ, Kris- etherton PM. Dietary linolenic acid reduces inflammatory and lipid cardiovasculr risk factors in hyperchoesterolemic men and women. J Nutr 2004; 134: 2991-2997

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Published

2019-07-22

How to Cite

Kuntarti, R., Sukmaniah, S., & Widia A. Jusman, S. (2019). Efek Bubuk Susu Kedelai terhadap Kadar Kolesterol LDL dan HDL Serum Wanita Perimenopause dengan Hiperkolesterolemia. Majalah Sainstekes, 4(2). https://doi.org/10.33476/ms.v4i2.908

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