• Werda Indriarti
  • Wijoto Wijoto



Plasma lactate level, NIHSS, acute thrombotic stroke


Recently, lactate has been recognized as energy resources for neuron metabolism. According to ANLS hypothesis, glucose being particularly uptaken by astrocyte is eventually metabolized via glycolisis. Lactate produced in astrocyte is then released into extracelluler matrix and uptaken by neuron then converted into pyruvate that used in oxydative metabolism. That proccess is resulted more ATP than that of conventional theory. A few in vitro studies has demonstrated that there is an increased of ATP in neuron at hypoxic condition, agreed with ANLS hypothesis. This study was aimed to learn the correlation between plasma lactate level and functional scale in acute thrombotic stroke patients. Forty patients with acute thrombotic stroke were admitted to neurology ward, dr. Soetomo General Hospital Surabaya in May until July 2013. Those patients had been examined for plasma lactate level using lactate-oxydase colorimetric method and functional scale by NIHSS (National Institute of Health Stroke Scale). The results showed that mean of age was 58,98 plus-minus 11,91 years old, plasma lactate level was 1,51 plus-minus 0,47 mmol/L, and mean of NIHSS was 6,83 plus-minus 2,978. There was negative correlation between plasma lactate level and functional scale measured by NIHSS in acute thrombotic stroke patients, which was statistically significant (r value -0,366 and p value 0,020).


Caplan LR, 2009. Caplan’s Stroke: A Clinical Approach, 4th ed. Philadelphia: Elsevier Saunders, pp. 48-50.

Chih CP &Roberts EL, 2003. Energy Substrates for Neurons During Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis. J Cereb Blood Flow Metab 23(11): 1263-81.

Dahlan MS, 2011. Statistik untuk Kedokteran dan Kesehatan, edisi kelima. Jakarta: Salemba Medika, hal. 167-188.

Genc S, Kumaz IA, Oziigen M, 2011. Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data. BMC Systems Biology 5: 162.

Goldstein LB, Adams R, Alberts MJ, et al, 2006. Primary Prevention of Ischemic Stroke A Guideline from the American Heart Association/ American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Council: Nutrition, Physical Activity, and Metabolism Council and Quality of Care and Outcomes Research Interdisciplinary Working Group. Stroke 37: 1583-1633.

Graham GD, Blamire AM, Rothman DL, et al, 1993. Early temporal variation of cerebral metabolites after human stroke A proton magnetic resonance spectroscopy study. Stroke 24: 1891-96.

Gunnerson KJ, 2011. Lactic acidosis. http://emedicine.medscape.com/article/167027. Diunduh pada 24 februari 2013.

Karaszewski B, 2006. Metabolic disturbances in brain ischemic regions in an experimental model and in humans.PhD thesis. University of Edinburg, pp. 1-80.

Maniega SM, Cvoro V, Chappell FM, et al, 2008. Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study. Neurology 71(24): 1993-99.

McCormick, MT, 2008. Hyperglycaemia, insulin and acute ischaemic stroke. MD thesis. University of Glasgow, pp. 1-318.

Misbach J&Soertidewi L, 2011. Epidemiologi Stroke. Dalam Soertidewi L, Jannis Y (Eds). Stroke: Aspek Diagnosis, Patofisiologi, Manajemen. Jakarta: Balai Penerbit UI, hal. 1-12.

Nandwani S, Saluja M, Vats M, et al, 2010. Lactic Acidosis in Critically Ill Patients. People’s Journal of Scientific Research 3(1): 43-48.

Ricci G, Volpi L, Pasquali L, et al, 2009. Astrocyte-neuron interactions in neurological disorders. J Biol Phys 35: 317-336.

Sastroasmoro S & Ismael S, 2008. Dasar-dasar Metodologi Penelitian Klinis, edisi ketiga. Jakarta: CV Sagung Seto, hal. 78-90, 112-125.

Uyttenboogaart M, Koch MW, Stewart RE, et al, 2007. Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke. Brain 130: 1626-1630.




How to Cite

Indriarti, W., & Wijoto, W. (2020). KORELASI KADAR LAKTAT DARAH DENGAN DERAJAT FUNGSIONAL BERDASARKAN NIHSS PADA PASIEN STROKE TROMBOTIK AKUT. Majalah Sainstekes, 2(1), 056–064. https://doi.org/10.33476/ms.v2i1.1640