Aktivitas Inhibitor α-Glukosidase Ekstrak Daun Toona sureni (Bl. ) Merr. sebagai Antihiperglikemik
Authors
-
Indah Permata Yuda
-
Aryenti Aryenti
-
Juniarti Juniarti
Keywords:
hiperglikemia, inhibisi α-glukosidase, Toona sureni (Bl.) MerrAbstract
Telah dilakukan kajian aktivitas penghambatan α-glukosidase oleh ekstrak daun surian (Toona sureni (Bl.) Merr ). Daun surian diekstraksi menggunakan maserasi bertingkat dengan berbagai pelarut: n-heksana, etil asetat dan metanol. Hasil yang didapatkan ekstrak daun surian memiliki aktivitas yang potensial sebagai penghambat α-glukosidase. Ekstraksi dengan metanol menunjukkan aktivitas penghambatan paling baik dengan nilai IC50 sebesar 4,41 ppm, nilai ini sebanding dengan strandar nojiromycin yang memiliki nilai IC50 sebesar 4,98 ppm, selanjutnya ekstraksi dengan etil asetat (nilai IC50 sebesar 7,21 ppm). Hasil ini menunjukkan ekstrak daun surian dapat digunakan untuk mengontrol glukosa darah dan pencegahan hiperglikemia.
References
Abbas G, Al-Harrasi AS and Hussain H. 2017. α- glucosidase Enzyme Inhibitors from Natural Products. Discovery and Development of Antidiabetic Agents from Natural Products. 251-269.
Abhar HSE and Schaalan MF. 2014. Phytotherapy in diabetes: Review on potential mechanistic perspectives. World
Journal of Diabetes. 5(2): 176-197.
ADA (American Diabetes Association). 2016. Standart of Medical Care in Diabetes. Diabetes Care. 39(1): 13-20.
Akhilesh K. 2012. Inhibition of α-glucosidase by Acacia nilotica prevents hyperglycemia along with improvement of diabetic complications via aldose reductase inhibition. J Diabetes Metab. 6:1–7.
Bel FG, Delso I, Tejero T and Merino P. 2014. Biosynthetic Pathways to Glycosidase Inhibitors. Post-print de Current Chemical Biology. 8:10-16.
Coman C, Rugina OD, Socaciu C. 2012. Plants and natural compounds with antidiabetic action. Not Bot Horti Agrob. 40:314-25.
Cuong PV, Minh NT and Hung NV. 2007. Triterpenes from Toona sureni Moora (Meliacea). J. Chem, 45: 214-219.
Dewi RT, Tachibana S and Darmawan. 2014. Effect on α-glucosidase inhibition and antioxidant activities of butyrolactone derivatives from Aspergillus terreus MC751. Med Chem Res. 23: 454-460.
Dipiro JT, Wells BG, Schwinghammer TL and Dipiro CV. 2015. Pharmacotherapy Handbook, Ninth edition. Mc Graw Hill Education. New York: 161-175.
Djam’an DF. 2003. Toona sureni (Blume) Merr., Seed Leaflet, Danida Forest SeedCentre, Denmark, 2003.
Ekaprasada MT, Nurdin H, Ibrahim S and Dachriyanus D. 2009. Antioxidant activity of methyl gallate isolated from the leaves of Toona sureni. Indonesian J. Chem.9(3):457-460.
Elya B, Basah K, Mun’im A, Yuliastuti W, Bangun A, Septiana EK. 2012. Screening of α- glucosidase inhibitory activity from some plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Journal of
Biomedicine and Biotechnology. 1-6.
Hong HC, Li SL, Zhang XQ, Ye WC and Zhang QW. 2013. Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea. (8): 19-27.
Kraus W and Kypke K. 1979. Surenone and surenin, two novel tetranortriterpenoids from Toona sureni [blume] merrill. Tetrahedron Letter, 20: 2715-2716.
Rouzbehan S, Moein S, Homaei A and Moein MR. 2017. Kinetics of α-glucosidase inhibition by different fractions of three species of Labiatae extracts: a new diabetes treatment model. Pharmaceutical Biology. 55(1):1483-88.
Sastroamidjojo AS. 1967. Obat Asli Indonesia. Dian Rakyat. Edisi ke-3, 344-355.
Shai LJ, Masoko P, Mokgotho MP, Magano SR, Mogale A, Boaduo N, Eloff JN. 2010. Yeast α-glucosidase inhibitory and antioxidant activities of six medicinal plants collected in Phalaborwa, South Africa. S Afr J Bot. 76:465-70.
Verspohl E. 2012. Novel pharmacological approaches to the treatment of type 2 diabetes. Pharmacol Rev. 64:188–237.
Yuhernita & Juniarti. 2009. Skrining awal bioaktifitas daun surian (Toona sureni (Bl.) Merr.) dengan metode Bhrine Shrimp Lethality Test (BSLT) dan perendaman 2,2-diphenyil-1-picrylhydrazyn (DPPH).
Jurnal Kimia Mulawarman. 6(2). 33-36.
Yuhernita & Juniarti. 2011. Analisis Senyawa Metabolit Sekunder dari Ekstrak Metanol Daun Surian yang Berpotensi seagai Antioksidan. Makara SAINS. 15(1): 48-52.
