Hubungan Invasi Miometrium pada Karsinoma Ednometrium dengan Invasi Limfovaskular dan Grade Histologik

shintia Christina, Chandra Kartika Setyaningsih, Puspa Pelita Sukma Hermawan

Abstract


Latar Belakang : Karsinoma endometrium menduduki urutan keenam kanker pada wanita. Faktor prediktor prognosis pada karsinoma endomerium adalah grade histologik, invasi miometrium dan invasi limfovaskular. Kejadian metastasis kelenjar getah bening melalui limfovaskular pada karsinoma endometrium meningkat dengan adanya invasi tumor ke miometrium yang lebih dalam. Tujuan : Pada penelitian ini ingin diketahui apakah invasi miometrium mempunyai hubungan dengan invasi limfovaskular dan grade histologik. Apakah semakin tinggi grade histologik maka kejadian invasi miometrium dan invasi limfovaskular semakin meningkat ? Metodologi : Penelitian analitik kategorik tidak berpasangan dan retrospektif dengan menilai ulang slide histopatologik pada karsinoma endometrium di RSUD Tarakan. Penilaian ulang meliputi grade histologik, invasi miometrium dan invasi limfovaskular. Hasil : Didapatkan hubungan yang bermakna antara invasi miometrium dengan kejadian invasi limfovaskular (p=0,029). Hubungan derajat histologik dengan kejadian invasi miometrium dan invasi limfovaskular didapatkan tidak bermakna pada penelitian ini.  Kesimpulan : Semakin tinggi grade histologik tidak meningkatkan kemungkin invasi ke miometrium maupun invasi limfovaskular, sedangkan invasi ke miometrium yang lebih dari setengah ketebalan miometrium meningkatkan kemungkinan adanya invasi limfovaskular yang berarti meningkatkan risiko metastasis.

 

 


Keywords


Karsinoma endometrium, invasi miometrium, invasi limfovaskular, derajat histologik.

References


Bieber EJ, Sanfilippo JS, Horowitz IR, Shafi MI. Clinical Gynecology. 2nd Ed. Cambridge: Cambridge University Press; 2015:p. 47.

American Cancer Society. Key statistic for endometrial cancer. Diunduh dari www.cancer.org, 28 Oktober 2018.

Hurt JK, Guile MW, Bienstock JL, Fox HE, Wallach EE. The johns hopkins manual of gynecology and obstetrics. 4th Ed. Philadelphia : Lippincott Williams & Wilkins; 2011: p. 560

Callahan TL, Caughey AB. Blueprints obstetric and gynecology. 5th Ed. Philadelphia : Lippincott Williams & Wilkins; 2009: p. 310-5.

DiSaia PJ, Creasman WT, Mannel RS, McMeekin DS, Mutch DG. Clinical gynecologic oncology. 9th Ed. Philadelphia : Eslsevier; 2018:p. 129-36.

Bain CM, Burton K, McGavigan CJ. Ilustrasi ginekologi. 6thed. Singapore : Elsevier; 2011:p. 203-9.

Anwar M, Baziad A, Prabowo RP. Ilmu kandungan. 3rded. Jakarta : Tridasa Primer; 2011:p. 15,302,303.

Zamani F, Goodarzi S, Hallaji F, Zamiri A, Deilami T, Malek M, et al. Diagnostic value of pelvic MRI for assessment of the depth of myometrial invasion and cervical involvement in endometrial cancer: comparison of new versus old FIGO staging. Iran J Radiol. 2012;9(4):202–8.

Amir DA. Hubungan antara derajat histologi pada karsinoma endometrium dengan usia dan kedalaman invasi ke miometrium di rsud tarakan 2012-2016; 2018. Skripsi Fakultas Kedokteran UKRIDA.

Drake RL, Vogi AW, Mitchell AWM. Gray’s basic anatomy. Singapore : Elsevier; 2012:p. 229-31.

Gartner LP, Hiatt JL. Color textbook of histology. 3rd ed. Philadelphia : Sauders Elsevier; 2009: p. 476-80.

Eroschenko VP. Atlas histologi DiFiore dengan korelasi fungsional. 12th ed. Jakarta : Penerbit Buku Kedokteran EGC; 2013:p. 522-31.

Carey WD. Current clinical medicine. 2nd ed. Philadelphia : Saunders Elsevier; 2010: p.1227-9

Kumar V, Abbas AK, Aster JC. Robbins basic pathology. 9thed. Philadelphia: Saunders Elsevier; 2013:p 692-5.

Ingledew PA, Verma P. Endometrial cancer (oncology modules). Diunduh dari www.learnoncology.ca, 2 November 2018.

Parra-Herran C. Endometrial carcinoma-general. Diunduh dari: www.pathologyoutlines.com/topic/uterusendometrialcarc.html, 2 November 2018.

Holman LL, Lu KH. The epidemiology of endometrial cancer. Glob. libr. Women’s med., (ISSN : 1756-2228) 2012; DOI 10.3843/GLOWM.10236

Crum CP, Lee KR, Nucci MR. Diagnostic gynaecologic and obstetric pathology. 2nd ed. Philadelphia : Saunders Elsevier; 2011: p. 518-23.

Silverman P. Oncologic imaging : a multidisciplinary approach. Philadelphia : Saunders Elsevier; 2012: p. 23.

Buthtoiarova TN, Brenner CA, Singh M. Endometrial carcinoma : role of current and emerging biomarkers in resolving persistent clinical dilemmas. Am J Clin Pathol 2016 Jan; 145: p. 9-17.

Practice Bulletin No.149 : Endometrial cancer. Obstet Gynecol. 2015; 125 (4):p. 1008,1009.

Barakat RR, Berchuck A, Markman M, Randall ME. Principles and practice of gynaecologic and oncology. 6th ed. Philadelphia : Lippincott Williams and Wilkins; 2013 (E-book)

Colombo N, Preti EM, Landoni F, Carinelli S, Marini C, Sessa C. Endometrial cancer : ESMO clinical practice guidelines for diagnosis , treatment, and follow up. Annals of oncology, 2013 Okt.; 26(6); p. vi33-8

Braun MM, Overbeek-wager EA, Grumbo RJ. Diagnosis and management of endometrial cancer. Am Fam Physician, 2016 Mar 15; 93(6):p. 468-74.

Niederhueber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE. Abeloff’s clinical oncology. 5thed. Philadelphia : Churchill Livingstone; 2014:p. 1576-8.

Hacker NF, Gambone JC, Hobel CJ. Hacker and moore’s essentials of obstetrics and gynecology. 5thed. Philadelphia : Saunders Elsevier; 2010:p. 428-30.

Gordon M, Ireland K. Pathology of endometrial carcinoma. Glob libr women’s med., (ISSN:1756-2228) 2008; DOI 10.3843/GLOWM.10238.

Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO classification of tumours of female reproductive organs. 4thed. Geneva : WHO Press; 2014:p. 121-33.

Niederhueber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE. Abeloff’s clinical oncology. 5thed. Philadelphia : Churchill Livingstone; 2014:p. 1576-8.

Reis RD, Burzawa JK, Tsunoda AT, Hosaka M, et al. Lymphovascular space invasion portennds poor prognosis in low-risk endometrial cancer. Int J Gynecol Cancer 2015 Sep, 15 (7):1292-4.

Winham WM, Lin D, Stone PJ, Nucci MR, Quick CM. Architectural versus nuclear atypia-defined FIGO grade 2 endometrial endometrioid adenocarcinoma (EEC) : A clinicopathologic comparison of 154 cases with clinical follow up. International Journal of Gynecological Pathology 2014, 33 : 120

Singh N, Hirschowitz L, Zaino R, Cabrero IA, Duggan MA, Ali-Fehmi R, et al. Pathologic prognostic factors in endometrial carcinoma (other than tumor type and grade). Int J Gynecol Pathol Dec 18. Diunduh dari https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296841/ , pada 23 September 2019.

Gadducci A, Cavazzana A, Cosio S, Tana R, Fanucchi A, Teti G, et al. Lymph-vascular space involvement and outer one-third myometrial invasion are strong predictors of distant haematogeneous failures in patients with stage I-II endometrioid type endometrial cancer. Anticancer Research 2009. Diunduh dari http://ar.iiarjournals.org/content/29/5/1715, pada 23 September 2019.




DOI: https://doi.org/10.33476/jky.v27i3.1204

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 YARSI Medical Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

__________________________________________________________________________________________

Copyright of YARSI Medical Journal.

Powered by OJS.

Creative Commons License

This work is licensed under a Creative Commons Attribution- NonCommercial 4.0 International License.