Perbandingan Efektifitas Chitosan Sisik Ikan Bandeng Dengan Gentamisin Terhadap Perkembangan Escherichia Coli

Zahdatul Khaira Ummah, Novita Sari, Jelita Fortuna, Elman Boy


Every infection caused bacteria in treatment necessary antibiotic substances. The use of antibiotics has reported resistance in all bacteria important pathogens because the use of inappropriate. Indonesia is maritime states having natural resources fisheries. besides the flesh can be consumed,  single scale having benefits as antimicroba. Chitosan is a polysaccharide from the deasetilasi chitin,  obtained in exoskeletons fish and animal skin Crustacea. Chitosan having the nature of antimicroba capable of inhibiting microorganisms like a fungus and bacteria having a functional amines. The purpose of this research is to find effectiveness in comparison chitosan scales a fish with antibiotics gentamicin to the development of E. Coli. This research is laboratory experimental with the post test only control group design. The result of this research shows differences in significantly between Chitosan with gentamicin to the development of bacteria E. Coli the first trust 95% with this One Way ANOVA stating the welfare between Chitosan and gentamicin of 0,000 (p is less than 0.05). Conclusion this research, Chitosan having a level the effectiveness of a high by concentration of the 0.25%. But in concentration 0.25% is still below the ability antibiotic gentamicin showing the rate of zone obstruent higher than chitosan by concentration of the 0.25%


Chitosan, Ikan Bandeng, Gentamisin, E. coli


Brooks GF, Butel SJ, Morse AS 2001. Medical microbiology. International Edition. 22nd ed. New York: McGraw-Hill Co.

Clinical Laboratory Standards Institute. 2017. Performance standards for antimicrobial susceptibility testing; 17th informational supplement, vol. 27, no. 1. M100-S17. Clinical Laboratory Standards Institute, USA

Fithria Z. 2017. Uji Efektivitas Konsentrasi Ekstrak Daun Sereh (Cymbopogon citratus) Terhadap Pertumbuhan Bakteri Streptococcus viridans Secara In Vitro. [Skripsi]. Universitas Muhammadiyah Sumatera Utara.

Ganiswarna 1995. Farmakologi dan Terapi. Penerbit EGC Kedokteran. Jakarta.

Hafdani, F.N. and Sadeghinia. N., 2011. A Review on Application of Chitosan as a Natural Antimicrobial. World Academy of Science. Engineering and Technology, 50.

Hardjasaputra P dkk 2002. Data Obat di Indonesia. Edisi 10. Penerbit : Grafidian Medipress.

Helander, E.-L., Nurmiaho-Lassila, Ahvenainen, R., Rhoades J. and Roller, S., 2001. Chitosan Disrupts The Barrier Properties of The Outer Membrane of Gram-Negative Bacteria. International Journal of Food Microbiology, 71: 235–244.

Holt GJ, Krieg RN, Sneath HAP, Staley HAP, Williams TS 1994. Enterobacteriaceae. In: Bergey’s manual of determinative bacteriology. International Edition. 9th ed. Maryland: Williams & Wilkins.

Istiantoro YH, dan Gan VHS 2007. Farmakologi dan Terapi, edisi V, FK-UI, Jakarta



  • There are currently no refbacks.

Copyright (c) 2017 YARSI Medical Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


Copyright of Jurnal Kedokteran YARSI.

Powered by OJS.

Creative Commons License

This work is licensed under a Creative Commons Attribution- NonCommercial 4.0 International License.