Efek Kemopreventif Ekstrak Etanolik Biji Jinten Hitam (Nigela sativa) pada Terjadinya Kanker Kulit Mencit Strain Terinduksi Ultraviolet

Authors

  • Sri Nabawati Nurul Makiyah Department of Histology and Cell Biology, Faculty of Medicine and Health Science, Muhammadiyah University of Yogyakarta

https://doi.org/10.33476/jky.v24i2.254

Keywords:

Efek kemopreventif, N.Sativa ekstrak etanol, kanker kulit

Abstract

Penelitian ini bertujuan untuk mengetahui efek kemopreventif ekstrak etanolik biji N. sativa terhadap terjadinya kanker kulit mencit terinduksi sinar UV. Mencit galur Balb-C dicukur punggungnya hingga bersih. Hewan uji dibagi menjadi 6 kelompok yaitu kelompok I-III diberi  ekstrak etanolik  biji N. sativa dengan dosis 100mg/kgBB, 200mg/kgBB, 400mg/kgBB, kontrol positif  yang diinduksi kanker dengan UV, kontrol negatif yang tidak mendapat perlakuan, dan kontrol  negatif diberi CMC (sebagai pelarut ekstrak). Disimpulkan bahwa ekstrak etanolik biji N. sativa setelah pemaparan ultraviolet menurunkan insidensi kanker kulit mencit sebesar 5,3%-43,2%,  menurunkan tumor multiplicity 45-55% tetapi secara statistik tidak signifikan, menunjukkan gambaran histopatologik kulit yang lebih baik, meningkatkan ekspresi p53 secara statistik berbeda signifikan.

References

Anonim 1979. Materia Medika. Jilid III. Departemen Kesehatan Republik Indonesia. Jakarta. 112.

Anonim 1985. Tumbuhan Obat Indonesia. Jilid I. Dep Kes RI. Jakarta. 41

Al Ghamdi MS 2001. The antiinflamatory, analgesic and antipyretic activity of Nigella sativa, 55: 379-382. Department of Pharmacology King Faisal University College of Medicine. www.elsevier.com. 2002

Backer CA, and van den Brink Jr., RCB 1968, Flora of Java, vol. II, Published Under The Auspices of The Ryksherbarium, Leiden

Badary OA, Gamal El-din AM 2001. Inhibitory effect of thymoquinone against 20-methylchlolanthrene-induced fibrosarcoma tumorigenesis. In Randhawa MA, Mastoor S and Al Ghamdi. 2002. A review of the pharmaco-therapeutic effects of Nigella sativa. Pakistan J. Med. Res. 41 (2).

Burits M, and Bucar F 2000. Antioxidant activity of Nigella sativa essential oil. Phytother Res. 14 (5):323-8

Budiyanto A 2005. UV-induced DNA damage, skin carcinogenesis, and its prevention dalam seminar “Peranan Biologi Molekuler dalam bidang kesehatan”, FK UGM Yogyakarta

Dhawan D, Balasubramanian S, Amonkar AJ, Singh N 1999. Chemopreventive effect of 4’-demethyl epipodophyllotoxin on DMBA/TPA induced mouse skin carcinogenesis. J of Carcinogen. 20(6): 997-1003

El-Kadi A, Kandil O 1986. Effect of Nigella sativa (the black seed) on immunity. In Randhawa MA, Mastoor S and Al Ghamdi. 2002. A review of the pharmaco-therapeutic effects of Nigella sativa. Pakistan J. Med. Res. 41 (2).

Elsayed I, and Fukushima S 2003. Chemopreventive potential of volatile oil from black cumin (Nigella sativa L) seeds against rat colon carcinogenesis. J. of Nutrit and Cancer. 45 (2):195-202

Hanahan D, and Weinberg RA 2000. The Hallmarks of Cancer, Cell, 100,57-70

Hutapea JR 1994. Inventaris Tanaman Obat Indonesia Jilid III. Departemen Kesehatan Republik Indonesia Badan Penelitian dan Pengembanagan Kesehatan. Jakarta.

Jones CLA 2000. Herbal Aids For Cancer. Nutrition Science News dalam Chiro.org. www. Chiro.org.

King RJB 2000. Cancer Biology, 2nd edition, Pearson Education Ltd., London

Mardisiswoyo, dan Rajakmangunsudarso 1985. Cabe Puyang Warisan Nenek Moyang. Balai Pustaka. Jakarta. 94-94

Meiyanto E 1999. Kurkumin sebagai anti-kanker; menelusuri mekanisme aksinya (Review), MFI, 10 (4 ),224-23

Mouhajir F, Pederson JA, Rejdali M, and Towers GHN 1999. Antimicrobial thymohydroquinones of Moroccan Nigella sativa seeds Detected by Electron Spin Resonance. J. of Pharmaceutic Biol. 1388 0209/99/3705-39

Mukhtar A 2002. Kanker kulit dalam Deteksi Dini Kanker, Balai Penerbit FK UI, 76-84

Nafrialdi, dan Gan S 1995. Antikanker. dalam Ganiswara, S.G. (ed.). Farmakologi dan Terapi Edisi 4. Bagian Farmakologi FKUI. Jakarta, 686 -701

Randhawa MA, Mastoor S, and Al Ghamdi 2002. A review of the pharmaco-therapeutic effects of Nigella sativa. Pakistan J. Med. Res. 41 (2).

Sukardja IDG 2000. Onkologi Klinik, Airlangga University Press, Surabaya

Surh Y 1999. Molecular Mechanism of Chemopreventive Effect of Selected Dietary and Medicinal Phenolic Substances, Mut Res, 428, 305-327

Surh Y 2003. Cancer Chemoprevention With Dietary Phytochemicals. Nature Revs.3. ; 768-80

Tjindarbumi D, dan Mangunkusumo R 2002. Cancer in Indonesia, Present and Future, Jpn J Clin Oncol ; 32 (Supplement 1) ,17-21

Triningsih E 2002. Kanker dan Permasalahannya dalam Seminar Pengobatan Komplementer pada Penderita Kanker, Yayasan Kucala Yogyakarta

Worthen Dr, Ghosheh OA, Crooks PA 1998. The in vitro anti-tumour activity of some crude and purified components of black-seed, Nigella sativa. In Randhawa MA, Mastoor S and Al Ghamdi. 2002. A review of the pharmaco-therapeutic effects of Nigella sativa. Pakistan J. Med. Res. 41 (2).

Zaoui A, Cherrah Y, Mahassini N, Alaovi K, Amarouch H, Hassar M 2002. Acute and Chronic Toxicity of Nigella sativa fixed oil, Phytomedicine 9 (1) : 69-74. www.elsevier.com. 2002

Downloads

Published

2017-01-26

Issue

Section

Research Articles