Antioxidant Activity and Anticarcinogenic Properties of “Sisik Naga”(Drymoglossum piloselloides Presl.)
Authors
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Susi Endrini
Department of Biochemistry, Faculty of Medicine YARSI University, Jakarta
Keywords:
MTT assay, “sisik naga”, MCF-7, Antioxidant activity, cytotoxic propertiesAbstract
The research was conducted to determine the anticarcinogenic properties of “sisik naga”(Drymoglossum piloselloides Presl.), by the microculture tetrazolium salt (MTT) assay on the human breast carcinoma dependenthormone (MCF-7) cell lines. The preliminary results showed that the “sisik naga” extract displayed the cytotoxic effects against MCF-7 with IC50 value of 83.63µg/ml. The antioxidative activity of the extracts which could contribute to their cytotoxic properties was also studied. The “sisik naga” extract was found to have high antioxidant activity with IC50-value of 4.229 ppm. The strong cytotoxic properties of the “sisik naga” extract could be due to its high antioxidant activity.References
Barbaste M,Berke´e B, Dumas M, Soulet S, Delaunay CL, Castagnino C, Arnaudinaud V, Che`eze C, Vercauteren J 2002. Dietary antioxidants, peroxidetion and cardiovascular risks. J.Nutr. Health Aging 6: 209–223.
Brand-Williams W, Cuvelier ME, Berset C 1995. Use of free radical method to evaluate antioxidant activity, Food Sci.Technol. (London) 28 : 25–30.
Hariana H 2006. Tumbuhan Obat dan Khasiatnya. Jakarta: Penebar Swadaya.
Heti D 2008. Uji sitotoksik ekstrak etanol 70% herba sisik naga (Drymoglossum piloselloides Presl.) terhadap sel T47D. Skripsi. Fakultas Farmasi Universitas Muhammadiyah Surakarta.
Kusuma FR, and BM Zaky 2005. Tumbuhan Liar Berkhasiat Obat. Jakarta: Agromedia Pustaka.
Susilowati LN 1988. Daya antibakteri daun Drymoglossum heterophyllum. Skripsi. Fakultas Farmasi Universitas Gadjah Mada.
Tjindarbumi D and R Mangunkusumo 2002.Cancer in Indonesia, Present and Future.Jpn J ClinOncol. 32 (supplement I): S17-S21.
Wijayakusuma H 2004. Atasi Kanker dengan Tanaman Obat. Jakarta: Puspaswara.
