Imunobiologi Sel Sertoli: Prospek Pemanfaatan Sel Sertoli bagi Alternatif Penanganan Cangkok Jaringan
Authors
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Sulaiman N Depamede
Laboratory of Microbiotechnology, Faculty of Animal Husbandry, University of Mataram and Laboratory of Immunobiology, Faculty of Mathematics and Natural Science,University of Mataram
Keywords:
allograft, immune privilege, blood testis barrier, diabetes, pancreasAbstract
Peran utama sel Sertoli adalah merawat dan mengatur perkembangan spermatozoa di dalam testis. Peran ini dilakukan secara anatomis fisiologis dengan membentuk blood testis barrier dan dengan mensekresikan beberapa faktor seperti Fas ligand dan transforming growth factors. Faktor-faktor tersebut berperan bagi terciptanya kondisi imunologis khusus di testis sehingga spermatozoa terlindung dari serangan sistem autoimun tubuh. Beberapa dekade terakhir, penelitian difokuskan pada upaya pemanfaatan sel Sertoli di luar habitat aslinya, sebagai imunosupresan alami dalam penanganan cangkok jaringan. Dalam tulisan ini dibahas beberapa upaya tersebut, dengan beberapa contoh kombinasi cangkok pankreas dan sel Sertoli dalam upaya menangani masalah diabetes melitus. Hasil-hasil penelitian menunjukkan ko-transplantasi sel Sertoli dan sel pankreas berdampak positif bagi perpanjangan usia cangkokan hingga 100 hari dibanding kontrol dengan efek positif bagi proses normoglycemic hewan coba. Di Indonesia penelitian tentang upaya pemanfaatan sel Sertoli sebagai salah satu upaya penanganan masalah cangkok jaringan masih terbatas, dengan demikian studi ini perlu dikaji lebih mendalam lagi.References
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