Protein kelompok BCl-2 sebagai target senyawa antikanker

Abstract

Recently, the mortality rate due to cancer has been increasing. This fact and the problem of cancer treatment in particular encourages the exploration of new alternative anticancer drugs from natural resources. The discovery of the new drugs requires explanation on their targets and mechanism of action. So far, in addition to alteration in the expression of proteins regulating apoptosis, some cancers demonstrate the presence of mutations in the tumor suppressor genes such as p53. These abnormalities would result in the destruction of apoptosis. Among targets of anticancer drugs through the modulation of apoptosis are BCl-2 family proteins which are able to release cytochrome c necessary for caspase activation. Anticancer drugs can stimulate the modulation of apoptosis on BCl-2 family targets by the modulation of oncogenes that can enhance the expession of tumor supressor genes which in turn influence the expression of pro-apoptosis or anti-apoptosis proteins.