Skrining Berbasis Ponsel Pintar: Alat Deteksi Midkine, Adiponectin¸ Apolipoprotein C-1, Kidney Injury Molecule-1 sebagai Biomarker Obstruksi Arteri Koroner

Authors

  • Ignatius Ivan Atma Jaya University
  • Maureen Miracle Stella Atma Jaya Catholic University of Indonesia http://orcid.org/0000-0003-2932-3498
  • Kevin Tandarto Atma Jaya Catholic University of Indonesia
  • Mariani Santosa Atma Jaya Catholic University of Indonesia

https://doi.org/10.33476/jky.v29i3.1415

Keywords:

Penyakit Jantung Koroner, Obstruksi Arteri Koroner, Ponsel Pintar, Biomarker

Abstract

Penyakit Jantung Koroner (PJK) adalah penyakit akibat penumpukan plak di dalam arteri koroner yang menyuplai oksigen ke jantung. Diketahui bahwa penyakit kardiovaskuler menyebabkan kematian sebanyak >17 juta orang setiap tahunnya dimana 42,3% diakibatkan oleh PJK. Melalui perkembangan teknologi kedokteran dan mengingat masyarakat dunia yang banyak memiliki ponsel pintar (6.4 triliun pengguna pada tahun 2021, maka kedua bidang ini mulai dikombinasikan. Cara deteksi biomarker ((midkine, adiponectin, apolipoprotein C-1 [ApoC-1], dan kidney injury molecule-1 [KIM-1]) melalui imunofluorosensi dengan alat portabel berbasis ponsel pintar dapat menjadi terobosan untuk mendeteksi Obstruksi Arteri Koroner yang Signifikan (OAKS). Dengan menggunakan konsep alat diagnosis portabel dan memiliki kemampuan multiplexing diharapkan 4 biomarker OAKS dapat terdeteksi dengan lebih mudah, cepat, tepat dan tanpa membutuhkan keahlian khusus sehingga pada akhirnya alat ini mampu menjangkau seluruh tingkat layanan kesehatan masyarakat terutama yang bersifat layanan primer.

Author Biographies

Ignatius Ivan, Atma Jaya University

Bachelor of Medicine

Maureen Miracle Stella, Atma Jaya Catholic University of Indonesia

Bachelor of Medicine

Kevin Tandarto, Atma Jaya Catholic University of Indonesia

Bachelor of Medicine

Mariani Santosa, Atma Jaya Catholic University of Indonesia

Physiology Department

Faculty of Medicine and Health Sciences

References

Authors/Task Force Members, 2006. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur. Heart J. 27, 1341–1381. https://doi.org/10.1093/eurheartj/ehl001

Berg, B., Cortazar, B., Tseng, D., Ozkan, H., Feng, S., Wei, Q., Chan, R.Y.-L., Burbano, J., Farooqui, Q., Lewinski, M., Di Carlo, D., Garner, O.B., Ozcan, A., 2015. Cellphone-Based Hand-Held Microplate Reader for Point-of-Care Testing of Enzyme-Linked Immunosorbent Assays. ACS Nano 9, 7857–7866. https://doi.org/10.1021/acsnano.5b03203

Burnham, C.-A.D., Doern, C., Binder, S.R., 2013. Viral Diseases 1, in: The Immunoassay Handbook. Elsevier, pp. 919–927. https://doi.org/10.1016/B978-0-08-097037-0.00073-7

Cardiovascular Stress Testing: A Description of the Various Types of Stress Tests and Indications for Their Use, 1996. . Mayo Clin. Proc. 71, 43–52. https://doi.org/10.4065/71.1.43

Chung, H.W., Ko, S.M., Hwang, H.K., So, Y., Yi, J.G., Lee, E.J., 2017. Diagnostic Performance of Coronary CT Angiography, Stress Dual-Energy CT Perfusion, and Stress Perfusion Single-Photon Emission Computed Tomography for Coronary Artery Disease: Comparison with Combined Invasive Coronary Angiography and Stress Perfusion Cardiac MRI. Korean J. Radiol. 18, 476. https://doi.org/10.3348/kjr.2017.18.3.476

Conti, C.R., 2009. Cardiovascular Studies and the Radiation Dose. Clin. Cardiol. 32, 56–57. https://doi.org/10.1002/clc.20592

Egli, P., Aeschbacher, S., Bossard, M., Eggimann, L., Blum, S., Meyre, P., Bargetzi, L., Estis, J., Todd, J., Risch, M., Risch, L.,

Conen, D., 2018. Relationships of kidney injury molecule-1 with renal function and cardiovascular risk factors in the general population. Clin. Chim. Acta 478, 13–17.

https://doi.org/10.1016/j.cca.2017.12.019

Gaggin, H.K., Bhardwaj, A., Belcher, A.M., Motiwala, S.R., Gandhi, P.U., Simon, M.L., Kelly, N.P., Anderson, A.M., Garasic, J.M., Danik, S.B., Schwamm, L.H., Gerszten, R.E., van Kimmenade, R.R.J., Januzzi, J.L., 2014. Design, methods, baseline characteristics and interim results of the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study. IJC Metab. Endocr. 5, 11–18. https://doi.org/10.1016/j.ijcme.2014.08.005

Ghani, L., Susilawati, M.D., Novriani, H., 2016. Faktor Risiko Dominan Penyakit Jantung Koroner di Indonesia. Bul. Penelit. Kesehat. 44. https://doi.org/10.22435/bpk.v44i3.5436.153-164

Gibbons, R.J., Balady, G.J., Timothy Bricker, J., Chaitman, B.R., Fletcher, G.F., Froelicher, V.F., Mark, D.B., McCallister, B.D., Mooss, A.N., O’Reilly, M.G., Winters, W.L., Gibbons, R.J., Antman, E.M., Alpert, J.S., Faxon, D.P., Fuster, V., Gregoratos, G., Hiratzka, L.F., Jacobs, A.K., Russell, R.O., Smith, S.C., 2002. ACC/AHA 2002 guideline update for exercise testing: summary article. J. Am. Coll. Cardiol. 40, 1531–1540. https://doi.org/10.1016/S0735-1097(02)02164-2

Gupta, A., Bajaj, N.S., 2017. Reducing radiation exposure from nuclear myocardial perfusion imaging: Time to act is now. J. Nucl. Cardiol. 24, 1856–1859. https://doi.org/10.1007/s12350-017-0915-y

Habibzadeh, F., Habibzadeh, P., Yadollahie, M., 2016. On determining the most appropriate test cut-off value: the case of tests with continuous results. Biochem. Medica 297–307. https://doi.org/10.11613/BM.2016.034

Hajian-Tilaki, K., 2013. Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Casp. J. Intern. Med. 4, 627–635.

Hanley, J.A., McNeil, B.J., 1982. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143, 29–36. https://doi.org/10.1148/radiology.143.1.7063747

Hosmer, D.W., Lemesbow, S., 1980. Goodness of fit tests for the multiple logistic regression model. Commun. Stat. - Theory Methods 9, 1043–1069. https://doi.org/10.1080/03610928008827941

Hu, J., Cui, X., Gong, Y., Xu, X., Gao, B., Wen, T., Lu, T.J., Xu, F., 2016. Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care. Biotechnol. Adv. 34, 305–320. https://doi.org/10.1016/j.biotechadv.2016.02.008

Ibrahim, N.E., Januzzi, J.L., Magaret, C.A., Gaggin, H.K., Rhyne, R.F., Gandhi, P.U., Kelly, N., Simon, M.L., Motiwala, S.R., Belcher, A.M., van Kimmenade, R.R.J., 2017. A Clinical and Biomarker Scoring System to Predict the Presence of Obstructive Coronary Artery Disease. J. Am. Coll. Cardiol. 69, 1147–1156. https://doi.org/10.1016/j.jacc.2016.12.021

Jiangping, S., Zhe, Z., Wei, W., Yunhu, S., Jie, H., Hongyue, W., Hong, Z., Shengshou, H., 2013. Assessment of Coronary Artery Stenosis by Coronary Angiography: A Head-to-Head Comparison With Pathological Coronary Artery Anatomy. Circ. Cardiovasc. Interv. 6, 262–268. https://doi.org/10.1161/CIRCINTERVENTIONS.112.000205

Katsiki, N., Mantzoros, C., Mikhailidis, D.P., 2017. Adiponectin, lipids and atherosclerosis: Curr. Opin. Lipidol. 28, 347–354. https://doi.org/10.1097/MOL.0000000000000431

Kementrian Kesehatan Republik Indonesia, 2013. Riset Kesehatan Dasar 2013.

Kementrian Kesehatan Republik Indonesia, n.d. Kementerian Kesehatan Republik Indonesia [WWW Document]. Penyakit Jantung Penyebab Kematian Tertinggi Kemenkes Ingatkan CERDIK. URL http://www.depkes.go.id/article/view/17073100005/penyakit-jantung-penyebab-kematian-tertinggi-kemenkes-ingatkan-cerdik-.html.

Krahwinkel, W., Ketteler, T., Godke, J., Wolfertz, J., Ulbricht, L.J., Krakau, I., Giilker, H., 2018. Dobutamine stress echocardiography. Eur Heart J 18, 7.

Lillehoj, P.B., Huang, M.-C., Truong, N., Ho, C.-M., 2013. Rapid electrochemical detection on a mobile phone. Lab. Chip 13, 2950. https://doi.org/10.1039/c3lc50306b

Maas, A., Appelman, Y.E.A., 2010. Gender differences in coronary heart disease. Neth. Heart J. 18, 598–602.

Marwick, T.H., Cho, I., ó Hartaigh, B., Min, J.K., 2015. Finding the Gatekeeper to the Cardiac Catheterization Laboratory. J. Am. Coll. Cardiol. 65, 2747–2756. https://doi.org/10.1016/j.jacc.2015.04.060

Ming, K., Kim, J., Biondi, M.J., Syed, A., Chen, K., Lam, A., Ostrowski, M., Rebbapragada, A., Feld, J.J., Chan, W.C.W., 2015. Integrated Quantum Dot Barcode Smartphone Optical Device for Wireless Multiplexed Diagnosis of Infected Patients. ACS Nano 9, 3060–3074. https://doi.org/10.1021/nn5072792

Mordi, I., Stanton, T., Carrick, D., McClure, J., Oldroyd, K., Berry, C., Tzemos, N., 2014. Comprehensive Dobutamine Stress CMR Versus Echocardiography in LBBB and Suspected Coronary Artery Disease. JACC Cardiovasc. Imaging 7, 490–498. https://doi.org/10.1016/j.jcmg.2014.01.012

Ontario, Ministry of Health and Long-Term Care, Medical Advisory Secretariat, Gibson Library Connections, I., 2010. Stress echocardiography with contrast for the diagnosis of coronary artery disease: an evidence-based analysis. Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care, Toronto, Ont.

Practitioners, T.R.A.C. of G., n.d. RACGP - Cardiac stress testing – stress electrocardiography and stress echocardiography [WWW Document]. URL https://www.racgp.org.au/afp/2012/march/cardiac-stress-testing/#1

Rallidis, L., Cokkinos, P., Tousoulis, D., Nihoyannopoulos, P., 1997. Comparison of Dobutamine and Treadmill Exercise Echocardiography in Inducing Ischemia in Patients With Coronary Artery Disease. J. Am. Coll. Cardiol. 30, 1660–1668. https://doi.org/10.1016/S0735-1097(97)00376-8

Sicari, R., Nihoyannopoulos, P., Evangelista, A., Kasprzak, J., Lancellotti, P., Poldermans, D., Voigt, J.-U., Zamorano, J.L., on behalf of the European Association of Echocardiography, 2008. Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur. J. Echocardiogr. 9, 415–437. https://doi.org/10.1093/ejechocard/jen175

Sung, Y., Campa, F., Shih, W.-C., 2017. Open-source do-it-yourself multi-color fluorescence smartphone microscopy. Biomed. Opt. Express 8, 5075. https://doi.org/10.1364/BOE.8.005075

Takemoto, Y., Horiba, M., Harada, M., Sakamoto, K., Takeshita, K., Murohara, T., Kadomatsu, K., Kamiya, K., 2018. Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice. Circ. J. 82, 19–27. https://doi.org/10.1253/circj.CJ-17-0043

Wei, Q., Qi, H., Luo, W., Tseng, D., Ki, S.J., Wan, Z., Göröcs, Z., Bentolila, L.A., Wu, T.-T., Sun, R., Ozcan, A., 2013. Fluorescent Imaging of Single Nanoparticles and Viruses on a Smart Phone. ACS Nano 7, 9147–9155. https://doi.org/10.1021/nn4037706

Westerterp, M., Berbée, J.F.P., Delsing, D.J.M., Jong, M.C., Gijbels, M.J.J., Dahlmans, V.E.H., Offerman, E.H., Romijn, J.A., Havekes, L.M., Rensen, P.C.N., 2007. Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification. J. Lipid Res. 48, 1353–1361. https://doi.org/10.1194/jlr.M700024-JLR200

WHO, n.d. Cardiovascular diseases (CVDs) [WWW Document]. World Health Organ. URL http://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).

Wong, N.D., 2014. Epidemiological studies of CHD and the evolution of preventive cardiology. Nat. Rev. Cardiol. 11, 276. https://doi.org/10.1038/nrcardio.2014.26

Zhu, H., Yaglidere, O., Su, T.-W., Tseng, D., Ozcan, A., 2011. Cost-effective and compact wide-field fluorescent imaging on a cell-phone. Lab Chip 11, 315–322. https://doi.org/10.1039/C0LC00358A

Published

2022-12-02