Peran Neuregulin-1 (NRG-1), Acidic Fibroblast Growth Factor (FGF), dan Vascular Endothelial Growth Factor (VEGF) pada Sel Perisit sebagai Inovasi Terbaru Penanganan Infark Miokard akibat Aterosklerosis

Ignatius Ivan, Nicolas Daniel Widjanarko, Harvey Sudharta, Maureen Miracle Stella, Kevin Tandarto, Mariani Santosa

Abstract


Infark miokard telah mengakibatkan 17 juta kematian di seluruh dunia pada tahun 2005. Hal ini terutama disebabkan karena terjadinya nekrosis sel miokard akibat iskemia jangka panjang. Agen trombolitik tidak memiliki pengaruh dalam meregenerasi pembuluh darah yang pecah. Oleh karena itu, banyak sel induk pembuluh darah, terutama perisit, dibawa untuk merangsang pembangunan, pematangan, rekonstruksi, dan mempertahankan permeabilitas pembuluh baru. Di sisi lain, beberapa faktor pertumbuhan seperti Neuregulin-1 (NRG-1), Acidic Fibroblas Growth Factor  (FGF), dan Vascular Endothelial Growth Factor (VEGF) juga memainkan peran dalam angiogenesis yang merupakan jalur utama proses penyembuhan akibat iskemia. Tujuan dari kajian ilmiah ini adalah untuk menjelaskan peran perisit yang distimulasi oleh leptin, bersama dengan beberapa faktor pertumbuhan yang diselubungi oleh mikropartikel sebagai terapi baru infark miokard yang terutama disebabkan oleh aterosklerosis. Hasil kajian menunjukkan bahwa perisit memiliki kemampuan untuk berdiferensiasi menjadi sel otot polos, sel saraf, dan sel endotel. Proses ini dipengaruhi oleh leptin dan juga beberapa faktor pertumbuhan yang diselubungi oleh mikropartikel untuk meningkatkan stabilitas dan imunitas terhadap makrofag. Terapi sel punca dengan menggunakan perisit yang distimulasi oleh leptin dan faktor pertumbuhan yang diselubungi oleh mikropartikel dapat menjadi metode pengobatan infark miokard yang menjanjikan di masa depan.

 

Keywords


sitokin, faktor pertumbuhan, sel punca, perisit, infark miokard

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DOI: https://doi.org/10.33476/jky.v29i1.1413

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