The Role of Reactive Oxygen Species (ROS) in Cancer Stem Cells
Authors
-
Febrial Hikmah
Keywords:
ROS, kanker, redoks, sel punca kanker, terapiAbstract
Reactive Oxygen Species (ROS) are aerobic metabolic byproducts, mainly produced by mitochondria. Most types of cancer contain high amounts of ROS. An increase in endogenous ROS triggers adaptive changes, induces oxidative stress and cytotoxic. Oxidative stress can lead to cancer. But on the other hand, the radiotherapy treatment method induces the formation of ROS in the process of cell death. Resistance therapy in cancer cells is associated with high antioxidant enzymes that neutralize ROS in cancer cells. In addition, therapeutic resistance and recurrence are also associated with the presence of cancer stem cells (CSC). Several studies have shown that ROS levels are found to be low in cancer stem cells. Low levels of ROS are likely to play a role in the survival of cancer stem cells. Therefore, modulation of ROS levels in cancer stem cells can be used as an alternative therapy.References
Almeida, CA, SA Barry. 2010. Cancer: basic science and clinical aspects. 1st ed. UK: Wiley-Blackwell, p 405.
Andreyev AY, YE Kushnareva, AA Starkov 2005. Mitochondrial metabolism of reactive oxygen species (review). Biochem. 70(2): 200-213.
Bours V, et. al. 1999. Nuclear factor-?B, cancer, and apoptosis. Biochem. Pharmacol. 60: 1085-1090.
Cipolleschi MG, et. al. 2002. The expansion of murine bone marrow cells preincubated in hypoxia as an in vitro indicator of their marrow-repopulating ability. Leukemia. 14: 735–739.
Dayem AA, HY Choi, JH Kim, SG Cho 2010. Role of oxidative stress in stem, cancer and cancer stem cells. Cancers. 2: 859-884.
Dey-Guha I, et. al. 2011. Asymmetric cancer cell division regulated by AKT. Proc. Natl. Acad. Sci. U.S.A. 108: 12845-12850.
Diehn M, et. al. 2009. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 458: 780-783.
Forman HJ, J Fukuto, M Torres (eds). 2004. Signal transduction by reactive oxygen and nitrogen species: pathways and chemical principles. New York: Kluwer Academic Publishers, p 410.
Gupta, et. al. 2012. Upsides and downsides of reactive oxygen species for cancer: The roles of reactive oxygen species in tumorigenesis, prevention, and Therapy (review). Antioxid. Redox Signal. 16: 1295-1322.
Halliwell B, Gutteridge JMC. 2007. Free radical in biology and medicine. 4th ed. London: Oxford University Press, p 30-74.
Hancock JT, R Desikan, SJ Neill 2001. Role of reactive oxygen species in cell signaling pathways. Biochem. Soc. Trans. 29: 345-350.
Jin Y, et. al. 2010. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 70: 2516-2527.
Karin M 2006. Nuclear factor-?B in cancer development and progression. Nature. 441: 431-436.
Kim HM, et. al. 2011. Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transitionlike phenomenon. Ann. Surg. Oncol.
Klaunig JE, LM Kamendulis 2004. The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44: 239-267.
Kurata S 2000. Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress. J. Biol. Chem. 275: 23413-23416.
Liou GY, P Storz 2010. Reactive oxygen species in cancer. Free Radic. Res. 44(5): 1-30.
Mates JM, M Francisca, S Jimenez 2000. Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int. J. Biochem. Cell Biol. 32: 157-170.
Morrison, SJ, J Kimble 2006. Asymmetric and symmetric stem-cell division in development and cancer. Nature. 44: 1069-1074.
Murphy MP 2009. How mitochondria produce reactive oxygen species (review). Biochem J. 417: 1-13.
Norman J, C Cellurale, RJ Davis 2007. A radical role p38 MAPK in tumor initiation. Cancer Cell. 11: 101-103.
Oliveira PA, et. al. 2007. Chemical carcinogenesis. An. Acad. Bras. Cienc. 79(4): 593-616.
Shi, X, Y Zhang, J Zheng, J Pan 2012. Reactive oxygen species in cancer stem cells. Antioxid. Redox Signal. 16(11): 1215-1228.
Tower J 2012. Stress and stem cells. Wiley Interdiscip. Rev. Dev. Biol. 1(6): 1-21.
Wanandi, SI et.al. 2013. Pengembangan terapi target sel punca kanker payudara manusia asal Indonesia. Jakarta: FKUI, p.1-11.
Wiestler OA, B Haendler, D Mumberg (eds). 2007. Cancer stem cells: nover concepts and prospects for tumor therapy. Berlin: Springer, p 264.
World Health Organization (WHO). World cancer report 2008 [internet]. 2009 [cited 2014 Feb 14]. Available from: www.who.int/cancer/publications/world_cancer_repport_2008/en.
Zhou, Y, EO Hileman, W Plunkett, MJ Keating, P Huang 2003. Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS generating anticancer agents. Blood. 101: 4098-4104.
