Effects of strobilanthes crispus extract on the apoptotic pathway of human liver carcinoma cell lines

Susi Endrini, Suherman Suherman, Asmah Rahmat, Patimah Ismail, Y.H Taufiq-Yap, Fauziah Othman

Abstract


Previous study has been shown the potential anticarcinogenic effect of Strobilanthes crispus, a plant native to countries from Madagascar to Indonesia, on human liver cancer (HepG-2) cell lines. The objective of the present study was to investigate the mechanism of anticarcinogenic effect
of S.crispus extract through apoptotic pathway. Exposure of HepG-2 cells to S.crispus extract resulted in induction of apoptosis in a dose-dependent manner as measured by Fluoresence Microscopy and Confocal Laser Scanning Microscopy analysis. These findings provide important new insight into the possible molecular mechanisms of the anticancer activity of S.crispus.


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DOI: https://doi.org/10.33476/jky.v15i1.998

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