Hubungan CXC Chemokine Receptor 4 (CXCR4) dan Matrix Metalloproteinase 9 (MMP 9) dengan Kemampuan Metastasis Adenokarsinoma Prostat

Sri Murtiyani, Bethy S. Hernowo, Sri Suryanti

Abstract


Karsinoma prostat merupakan keganasan kedua terbanyak pada laki-laki dan merupakan penyebab kematian kelima diseluruh dunia. Faktor prognosis utama pada adenokarsinoma prostat adalah metastasis yang menyebabkan tingginya angka kematian. Keadaan ini disebabkan karena pada kasus adenokarsinoma prostat yang metastasis pilihan terapi belum mendapatkan hasil yang memuaskan karena terdapat faktor resisten terhadap terapi radiasi dan kemoterapi. CXCR4 dan MMP 9 merupakan petanda imunohistokimia yang berfungsi dalam proses migrasi, chemotaxis dan detachment yang memegang peranan terhadap terjadinya metastasis pada adenokarsinoma prostat. Tujuan penelitian ini adalah mencari hubungan imunoekspresi CXCR4 dan MMP 9 dengan metastasis pada adenokarsinoma prostat.

Penelitian ini menggunakan desain potong lintang dan observasional analitik. Sampel diambil dari blok parafin yang tersedia di Departemen Patologi Anatomi RSUP Dr. Hasan Sadikin Bandung pada periode 2010-2016. Jumlah sampel sebanyak 52 sampel, dibagi menjadi 2 kelompok, yaitu kelompok metastasis 26 sampel dan kelompok non metastasis 26 sampel. Keseluruhan sampel dilakukan pulasan imunohistokimia CXCR4 dan MMP 9.

Hasil penelitian ini menunjukkan bahwa 71% sampel mengekspresikan CXCR4 kuat dengan proporsi terbesar pada kelompok metastasis (nilai p=0,000) dan 56% sampel mengekspresikan MMP 9 lemah pada kelompok metastasis (nilai p=0,55).

CXCR4 dapat digunakan sebagai faktor prediksi metastasis pada adenokarsinoma prostat.

Keywords


Adenokarsinoma prostat, CXCR4, metastasis, MMP 9, non metastasis

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DOI: http://dx.doi.org/10.33476/jky.v27i1.799

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