Pengaruh Waktu Latihan terhadap Peningkatan Aktivitas Fibrinolisis pada Latihan Aerobik Intensitas Sedang

Nawanto A. Prastowo

Abstract


The incremental of tissue-type plasminogen activator (t-PA) level during aerobic exercise is affected by time of the day. Previous studies showed that high intensity of aerobic exercise in the afternoon increased t-PA level higher than exercise in the morning. The purpose of this study was to examine the influence of time of the day on t-PA level during moderate intensity of aerobic exercise. Subjects were 16 sedentary, aged 25-35 years, healthy untrained male, performed two sessions of static ergocycling at 65-70% heart rate maximal (220-age), both in the morning (06.30-08.30) and in the afternoon (15.00-17.00) at least on two days interval. Wilcoxon signed rank test showed t-PA level increased significantly after exercise in the morning (P=0.00) and in the afternoon (P=0.00), but showed no significant difference in the magnitude of t-PA incremental (triangle t-PA) between post-exercise in the morning and in the afternoon (P=0.14). It was concluded that time of the day did not affect the magnitude of the tPA incremental in moderate intensity of aerobic exercise.

Keywords


tissue-type plasminogen activator; diurnal variation; aerobic exercise; moderate intensity

Full Text:

PDF

References


American College of Sport Medicine 2006. ACSM’s guidelines for exercise testing and prescription. 7th eds. Pennsylvania:Lippincott Williams & Wilkins, p 4.

Angleton P, Chandler WL, Schmer G 1989. Diurnal variation of tissue-type plasminogen activator (t-PA) and its rapid inhibitor (PAI-1). Circulation. 79; 101-106.

Barbeau P, Litaker MS, Woods KF, et al 2002. Hemostatic and inflammatory makers in bese youth: effects of exercise and adiposity. J. Pediatr. 141: 415-420.

BjÖrkman JA, Jern S, Jern C 2003. Cardiac sympathetic nerve stimulation triggers coronary t-PA release. Arterioscler. Thromb.Vasc. Biol.23: 1091-1103.

Clifford PS, Hellsten Y 2004. Skeletal and cardiac muscle blood flow vasodilatory mechanism in contracting skeletal muscle. J. Appl. Physiol. 97: 393-403

DeSouza CA, Jones PP, Seals DR 1998. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arterioscler. Thromb. Vasc. Biol.18: 362368.

DeSouza CA, Dengel DR, Rogers MA, Cox K, Macko RF 1997. Fibrinolytic responses to acute physical activity in older hypertensive men. J. Appl. Physiol. 82:1765-1770.

El-Sayed MS, Nieuwenhuizen W 2000. The effect of alcohol ingestion on the exercise-induced changes in fibrin and fibrinogen degradation product in man. Blood Coagul & Fibrinol. 11(4): 359-365.

Franklin BA, Balady GJ, Blair SN, et al 2007. AHA scientific statement. Exercise and acute cardiovascular events. Placing the risk into perspective: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and tha Council on Clinical Cardiology. Circulation. 115:2358-2368.

Giannarelli C, De Negri F, Virdis A, et al 2007. Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients. Hypertension. 49:878-889.

Hao Z, Guo C, Jiang X et al 2006. New transgenic evidence for a system of sympathetic axon able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls. Blood. 108(1): 200-213.

Healthy People 2010, 2001. Leading health indicator physical activity. www.healthy people.gov

Huber D, Cramer EM, Kaufmann JE, et al 2002. Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo. Blood. 99(10): 3637-3645.

Lee KW, Gregory YHL 2003. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity. A systematic review. Arch. Intern. Med. 163: 2368-2392.

Magaudda L, Di Mauro D, Trimarci f, Anastasi G 2004. Effect of physical exercise on skeletal muscle fiber: ultrastructural and molecular aspects. Basic. Appl. Myol. 14(1): 17-21.

McArdle WD, Katch FI, Katch VL 2006. Essentials of exercise physiology. 3rd eds. Philadelphia: Lippincott Williams &Wilkins, p 356.

Morris PJ, Packianathan CI, Van Blerk CJ, Finer N 2003. Moderate exercise and fibrinolytic potential in obese sedentary men with metabolic syndrome. Obes. Research. 11: 1333-1338.

Murray PM, Herrington DM, Pettus CW, et al 1993. Should patients with heart diseases exercise in the morning or afternoon? Arch. Intern. Med. 153:833-836.

Muller JE, Tofler GH, Verrier RL 1995. Sympathetic activity as the cause of the morning increase in cardiac events. A likely culprit, but the evidence remains circumstantial. Circulation: 2508-2511.

Otto ME, Svatikova A, Barretto RBM, et al 2004. Early morning attenuation of endothelial function in healthy humans. Circulation. 109: 2507-2510.

Rauramaa R, Li G, Väisänen SB 2001. Dose-response and coagulation and hemostatic factors. Med. Sci. Sports Exerc. 33(6) Suppl: S516-S520.

Ridderstråle W, Ulfhammer E, Jern S, Hrafnkelsdóttir T 2006. Impaired capacity for stimulated fibrinolysis in primary hypertension is restored by antihypertensive therapy. Hypertension. 47:686-692.

Ridker PM, Brown NJ, Vaughan DE, Harrison DG, Mehta JL 2004. Markers of malign across the cardiovascular continuum: interpretation and application established and emerging plasma biomarkers in the prediction of first atherothrombotic events. Circulation. 109: IV-6 – IV-19.

Smith JK 2001. Exercise and atherogenesis. Exerc Sport Sci Rev. 29:49-53

Szymanski LM, Pate RR 1994a. Effect of exercise intensity, duration, and time of day on fibrinolytic activity in physically active men. Med. Sci. Sports Exerc. 26(9): 1102-1108.

Szymanski LM, Pate RR 1994b. Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men. Arterioscler. Thromb. Vasc. Biol. 14: 1746-1750.

Van den Burg PJM, Hospers JEH, Mosterd WL, Bouma BN, Huisveld IA 2000. Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products. J. Appl. Pysiol. 88: 1558-1564.

Weiss C, Seitel G, Bärtsch P 1998. Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects. Med. Sci. Sports Exerc. 30(2): 246-251.

Willich SN, Lewis M, Lowel H, et al 1993. Physical exertion as a trigger of acute myocardial infarction. N. Engl. J. Med. 329:1684-1690.

Womack CJ, Ivey FM, Gardner AW, Macko RF 2001. Fibrinolytic response to acute exercise in patients with peripheral arterial disease. Med. Sci. Sports Exerc. 33(2): 214-219.

Yarnell JWG, Sweetnam PM, Rumley A, Lowe GDO 2000. Lifestyle

and hemostatic risk factors for ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. 20: 271-279.




DOI: https://doi.org/10.33476/jky.v16i1.226

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 YARSI Medical Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

__________________________________________________________________________________________

Copyright of YARSI Medical Journal.

Powered by OJS.

Creative Commons License

This work is licensed under a Creative Commons Attribution- NonCommercial 4.0 International License.