Analisis rasio IFNy - IL 4 pada berbagai kelompok Nefritis Lupus

Kusworini Handono

Abstract


Lupus Nephritis (LN) is a serious manifestation of Systemic Lupus Erythematosus (SLE), that is classified into 6 different classes according to WHO criteria. It has been shown that histological pattern of LN varied significantly among the class and the etiology of the difference in the histological phenotypes remains unknown to date. Several studies indicatedassociation between Th1/Th2 cytokines balance with genetic factor. The present study aims to evaluate the interferron-? (IFNy) / interleukin 4 (IL4) ratio among different histologicalphenotype of LN patients in Indonesia. The study was conducted in 40 female SLE patients at Dr. Saiful Anwar Hospital, Malang, Indonesia. Histologic phenotypes classification was based on WHO criteria (1995). The serum level of IFNy and IL4 was assayed using ELISA and the association between IFNy-IL4 ratio with the histological phenotypes was statistically analyzed using ANOVA. The study revealed that among 31 SLE subjects undergone renal biopsy, class I/II, class III/IV and class V were observed in 13, 12 and 6 subjects respectively. The IFNy-IL4 ratio in class III/IV subjects was significantly higher compared to those in the other classes (p<0.000). However, the IL4 in the class III/IV was significantly lower than the other classes. The findings indicated that the activity of the Th1 immune response tend to be higher in class III/IV LN patients whereas in class V LN patients, the Th2 response prevail. In conclusion, the study indicated that the IFNy-IL4 cytokine ratio might influence the pathogenesis of LN.

Keywords


Lupus Nephritis; histological phenotype; IFN?-IL4 ratio

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References


Bastian HM, Alar?on GS, Roseman JS, et al., 2007. Systemic Lupus Erythematosus in multiethnic US cohort (LUMINA) XL II : factors predictive of new or worsening proteinuria. Rheumatol 46: 683-689.

Chan RW-Y, Lai FM-M, Li EK-M, et al., 2006. Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. Rheumatol 45:951-

Contreras G, Pardo V, Cely C, Borja E, Hurtado A, Cuesta CDL, et al., 2005. Factors associated with poor outcomes in patients with lupus nephritis. Lupus 14:890.

D’Agati VD and Appel GB 2007. Lupus Nephritis: Pathology and Pathogenesis. In. Wallace DJ and Hahn BH (eds). Dubois’ Lupus Erythematosus, 7 th ed, Lippincot Williams & Wilkins, Philadelphia: 1094- 1108.

Houssiau F and Ginzler E 2008. Current treatment of lupus nephritis. Lupus; 17:426-30.

Korbet SM, Schwartz MM, Evans J, et al., 2007. Severe lupus nephritis: racial differences in presenta-tion and outcome. J Am Soc Nephrol 18: 244-254.

Mak A, Mok C, Chu W, To C, Wong S, Au T 2007. Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups. Lupus 16:28-34.

Mason L and Berden J 2008. Pathogenic factors for the development of lupus nephritis. Lupus 17:251.

Masutani K, Akahashi M, Tsuruya K, et al., 2001. Predominance of Th1 immune response in diffuse proliferative lupus nephritis. Arthritis Rheum 44:2097-2106.

Mathian A, Weinberg A, Gallegos M, et al., 2005. IFNa induces early lethal lupus in preautoimmune (NZ Black x NZ White) F, but not in BALB/c Mice. J Immunol 174:2499-2516.

Miyake K, Nakashima H, Akahoshi, M, Inoue Y, et al., 2002. Genetically determined interferon-y production influences the histological phenotype of lupus nephritis. Rheumatology 41: 518-24.

Oates J 2007. Renal biopsy at the onset of clinical lupus nephritis: can it yield useful information? J Rheumatol 34:256 - 8.

Peterson KS and Wuchester R 2005. Systemic lupus erythematosus: patogenesis. In.Koopman N J, Moreland LW (eds). Arthritis and Allied conditions. A Text book of Rheumatology 15th ed.Vol 2, Philadelphia , William & Wilkins,15231559.

Rönnblom l and Alm GV 2003. Systemic lupus erythematosus and the type I interferon system. Arthritis Res.Ther 5: 68-75.

Uhm WS, Na K, Song GW, Jung SS, Lee T, Park MH and Yoo.DH 2003. Cytokine balance in kidney tissue from lupus nephiritis patients. Rheumatology 42:935-938.

Waldman M and Madaio M 2005. Pathogenic autoantibodies in lupus nephritis. Lupus 14:19-24.

Weening J, D'Agati VD, Schwartz MM, Seshan SV 2004. The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. J Am Soc Nephrol 15:241-50.




DOI: https://doi.org/10.33476/jky.v17i2.206

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