Kadar Adiponektin pada subyek obes dengan maupun tanpa Resistensi Insulin

Hariadi Hariawan

Abstract


Adiponektin adalah suatu adipositokin yang dihasilkan dari jaringan lemak. Adiponektin mempunyai peranan penting dalam regulasi dari metabolisme glukosa dan resistensi insulin. Penelitian klinis menunjukkan bahwa kadar adiponektin lebih rendah pada subyek obes, diabetes dan penderita penyakit arteri koroner. Studi ini meneliti perbedaan kadar adiponektin pada subyek obes dengan resistensi inulin. Tujuan penelitian ini adalah untuk mengetahui perbedaan kadar adiponektin antara subyek obes dengan resistensi insulin dibandingkan subyek obes normal. Kadar adiponektin plasma diperiksa pada 72 subyek dengan indeks massa tubuh (IMT) >25kg/m2. Resisitensi insulin diukur dengan menggunakan formula homeostasis model assessment insulin resistance (HOMA IR) dari kadar insulin dan glukosa puasa. Kadar adiponektin plasma diukur dengan teknik ELISA. Diperiksa kadar glukosa darah, insulin dan profil lipid puasa. Hasilnya menunjukkan bahwa usia rerata adalah 46.39±6.45 tahun dengan IMT 29.83±3.57 kg/m2 dan kadar adiponektin 4.2±1.79 ?g/ml. Kadar adiponektin lebih rendah bermakna pada subyek obes. Kadar adiponektin tidak berbeda bermakna antara subyek obes dengan dan tanpa resistensi insulin (P=0.41). Tidak ada perbedaan proporsi seks diantara subyek obes dengan dan tanpa resistensi insulin (p=0.374). Analisis regresi logistik menunjukkan perbedaan dalam IMT, lingkar pinggang dan kadar glukosa 2 jam setelah makan pada subyek dengan resistensi insulin. Dari penelitian ini tidak didapatkan adanya perbedaan kadar adiponektin pada subyek obes yang mengalami resistensi insulin dan yang tidak mengalami resistensi insulin.

Keywords


adiponektin; resistensi insulin; obes

Full Text:

PDF

References


Bacha F & Saad R 2004. Adiponectin in Youth: Relationship to Visceral

Adiposity, Insulin Sensitivity and BCell Function, Diabetes Care, 27:547-552

Bray GA 2004. Obesity is a Chronic, Relapsing Neurochemical Disease. Int J Obes Relat Metab Disorder.; 28: 34-38

Chandran M, Philips SA, Ciaraldi T, Henry RR 2003. Adiponectin: More Than Just Another Fat Cell Hormone? Diabetes Care.; 26: 2442-2450

Choi KM, Lee J, Lee KW, Seo JA 2004. Serum Aduponectin Concentrations Predict the Development of Type 2 Diabetes and the Metabolic Syndrome in the Elderly Koreans. Clinical Endocrinology.; 61: 75-80

Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A 2003. Decreased Serum Levels of Adiponectin Area a Risk Factor for the Progression to Type 2 Diabetes in the Japanese Population. Diabetes Care.; 26: 20152020

Dulloo AG, Antic V, Montani JP 2006. Pathogenesis of the Worst Killer of the 21 st Century. Int J Obese Relat Metab Disord.; 26 (2): S1-S2

Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J, Mohlig M, Pfeiffer A, Luft FC 2003. Association between Adiponectin and Mediators of Inflammation in Obese Woman. Diabetes.; 52: 942-947

Havel PJ 2004. Update on Adypocytes Hormones. Regulation of Energy Balance and Carbohydrate/ Lipid Metabolism. Diabetes. 2004; 53 (1): S143-S1152.

Hotta K, Funahashi T, Arita Y 2000. Plasma Concentrations of a Novel, Adipose Specific Protein, Adiponectin, in Type 2 Diabetic Patients. Arterioscler Thromb Vasc Biol.; 20:1595-1599

Jazet IM, Pijl H, Meinders AE 2003. Adipose Tissue as an Endocrine Organ: Impact on Insulin Resistance. Neth J Med.; 61: 194-212

Kahn BB, and Flier JS 2000. Obesity and Insulin Resistance. J Clin Invest.; 106 (4): 473-481

Ling Lu H 2006. Roles of Adipocyte Derived Hormone Adiponectin and Resistin in Insulin Resistance of Type 2 Diabetes. World J Gastroenterol.; 12(11): 17471751

Matsubara M, Maruoka S, and Katayose S 2002. Inverse Relationship between Plasma Adiponectin and Leptin Concentrations in Normal Weight and Obese Women. Eur J Endocrinology.; 147: 173–180

Matsuzawa Y, Funahashi T, Kihara S, Shimomura I 2004. Adiponectin and Metabolic Syndrome. Aterioscler Thromb Vasc Biol.; 24: 29-33

Miyazaki Y, Glass L, Triplitt C, Wacjberg E 2002. Abdominal Fat Distribution and Peripheral and Hepatic Insulin Resistance in Type 2 Diabetes Mellitus. Am J Physiol Endocrinol Metab.; 283: E1135–E1143.

Okamoto Y, Kihara S, Funahashi T, Matsuzawa Y 2006. Adiponectin: A Key Adipocytokine in Metabolic Syndrome. Clinical Science.; 110: 267-278

Ramachandran A, Snehala 2003. Impaired Fasting Glucose and Impaired Glucose Tolerance in Urban Population in India. Diabetes Care.; 20: 220-224

Rattarasarn C 2006. Physiological and Pathophysiological Regulation

of Regional Adipose Tissue in the Development of Insulin Resistance and Type 2 Diabetes. Acta Physiol.; 186: 87–10

Rattarasarn C, Leelawattana 2003. Relationships of Body Fat Distribution, Insulin Sensitivity and Cardiovascular Risk Factors in Lean, Healthy Nondiabetic Thai Men and Women. Diabetes Res Clin Pract.; 60: 87–94.

Ruan H 2004. Regulation of Insulin Sensitifity by Adipose Tissue Derived Hormones and Inflammatory Cytokines.Cur Opion Lipidol.; 15: 297302

Schulze MB, Rimm EB, Shai I, Rifai N, Hu FB 2004. Relationship between Adiponectin and Glicemic Control, Blood Lipids, and Inflammatory Penandas in Men with Type 2 Diabetes. Diabetes Care.; 27:1680-1687

Simmons D, and Thompson CF 2003. Prevalence of the Metabolic Syndrome Adult New Zealanders. Diabetes Care; 27 (12):3002-3004

Snehalatha C, Mukesh B 2003. Plasma Adiponectin Is an Independent Predictor of Type 2 Diabetes in Asian Indians. Diabetes Care.; 26: 3226-3229

Trujillo ME 2005. Adiponectin - Journey from an Adipocyte Secretory Protein to Biomarker of the Metabolic Syndrome. J Intern Med.; 257: 167-175

Weyer C, Funahashi, Tanaka S, Hotta K 2001. Hypoadiponectinemia in Obesity and Diabetes melitus tipe 2: Close Association with Insulin

Resistance and Hyperinsulinemia; J Clin Endocrinol Metab.; 86: 1930-1935

Winzer C, Wagner O, Festa A, Schneider B, Roden M 2004. Plasma Adiponectin, Insulin Sensitivity and Subclinical Inflammation in Women with Prior Gestational Diabetes Mellitus. Diabetes Care.; 27:1721-1727

Yang WS, Lee WJ, Funahashi T, Tanaka S 2002. Plasma Adiponectin Levels in Overweight and Obese Asians. Obesity Research.; 10 (11):1104-1110

Yu JG, Javorsci S, Hevener AL, Kruszynska YT, Norman RA 2002. The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese and Type 2 Diabetes Subjects. Diabetes.; 51: 2968-2974




DOI: https://doi.org/10.33476/jky.v18i1.176

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 YARSI Medical Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

__________________________________________________________________________________________

Copyright of YARSI Medical Journal.

Powered by OJS.

Creative Commons License

This work is licensed under a Creative Commons Attribution- NonCommercial 4.0 International License.