Cytotoxic activity of Ethyl-p-Methoxycinnamate from Kaempferia galanga in HSC-4 Oral Cancer Cells

Wastuti Hidayati Suriyah; Abdul Razak Kasmuri; Muhammad Lokman Md. Isa; Solachuddin  J. A. Ichwan

Authors

Wastuti Hidayati Suriyah Universitas YARSI
Abdul Razak Kasmuri International Islamic University Malaysia
Muhammad Lokman Md. Isa International Islamic University Malaysia
Solachuddin J. A. Ichwan Universiti Brunei Darussalam

Abstract

Abstract

Introduction: Oral cancer is a prevalent malignancy associated with high mortality and morbidity, primarily due to its poor prognosis. Recently, phytomedicines have attracted interest for their potential role in chemotherapy. Kaempferia galanga, a medicinal herb, has shown anticancer properties in various human cancer cell lines, mainly due to its active compound, ethyl-p-methoxycinnamate (EPMC). Objective: This in vitro study aimed to assess the cytotoxic effects of EPMC on the HSC-4 oral cancer cell line. Materials and Methods: HSC-4 cells were treated with various concentrations of EPMC for 24 hours, and cytotoxicity was measured using the MTT assay. Results: EPMC exhibited dose-dependent cytotoxicity, with an IC50 value of 0.032 mg/mL. Discussion: These findings suggest that EPMC is a promising anticancer agent. Further research should investigate its molecular mechanisms and potential as a chemosensitizer when combined with standard chemotherapeutic drugs. Conclusion: EPMC induces cytotoxicity in HSC-4 cells, positioning it as a promising candidate for further exploration in oral cancer treatment.

Keywords: Cytotoxicity, EPMC, HSC-4, Oral Cancer

References

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