The differences of antibiotics effectiveness in therapy of thypoid fever without complications in children at Putra Bahagia Hospital, Cirebon


  • Muhammad Nurhanif Faculty of Medicine, Yarsi University, Jakarta Pusat 10510
  • Insan Sosiawan A Tunru Departement of Anatomical Pathology, Faculty of Medicine, Yarsi University, Jakarta Pusat 10510


Typhoid fever, Antibiotics, Fever’s free-time, The duration of treatment


Background: Typhoid fever remains a health problem, particularly in Indonesia and other developing countries. There are few selection of antibiotics that used for the treatment of typhoid fever.

Objective: The purpose of this research was to determine the antibiotic used in the treatment of typhoid fever without complications in children at Putera Bahagia Hospital Cirebon and to see the difference effectiveness.

Methods: The research was conducted in retrospective, that is taking medical records of pediatric patients aged 1-15 years with a diagnosis of typhoid fever at Putera Bahagia Hospital, Cirebon, periode of 2011-2014. Statistical analysis was performed using Kruskal-Wallis test, with SPSS 23 program. Results: Found 117 cases that met the inclusion criteria and antibiotics used are chloramphenicol (23.08%), cefixime (11.97%), cefotaxime (11.11%), ceftriaxone (49.57%), and azitromisin (4.27%). The fastest fever’s free-time is ceftriaxone, 42.46 hours (average time) and the shortest treatment duration is azithromycin, which is 4.8 days.

Conclusion: In this research, there was no significant difference between fever’s free-time and treatment duration of chloramphenicol, cefixime, cefotaxime, ceftriaxone, and azithromycin.


Adisasmito, A. W. (2006). Penggunaan Antibiotik pada Terapi Demam Tifoid Anak di RSAB Harapan Kita. Sari Pediatri , 174-180.

Brunton, L., Chabner, B., & Knollman, B. (2011). Goodman & Gilman’s Pharmacological Basis of Therapeutics (12th ed.). New York: The Mc-Graw-Hill Companies, Inc.

Butler, T. (2011). Treatment of Typhoid Fever in The 21st Century: Promises and Shortcomings. Clinical Microbiology and Infection , 17, 959-963.

Crump, J. A., Luby, S.P., & Mintz, E. D. (2004). The global burden of typhoid fever. Bull World Health Organ, 82, 346- 353.

Ekinci, B., Coban, A. Y., Birinci, A., Durupinar, B., & Erturk, M. (2002). In Vitro Effects of Cefotaxime and Cieftriaxone on Salmonella Typhi within Human Monocyte-derived Macrophages. Clinical Microbiology and Infection, 8, 810-813.

Fithria, R. F., Damayanti, K., & Fauziah, R. P. (2015). Perbedaan Efektivitas Antibiotik pada Terapi Demam Tifoid di Puskesmas Bancak Kabupaten Semarang Tahun 2014. Peluang Herbal Sebagai Alternatif Medicine. Semarang: Fakultas Farmasi Universitas Wahid Hasyim.

Frenck, R. W., Mansour, A., Nakhla, I., Sultan, Y., Putnam, S., Wierzba, T., Morsy, M., & Knirsch, C. (2004). Short-Course Azithromycin for the Treatment of Uncomplicated Tphoid Fever in Children and Adolescents. Clinical Infectious Disease, 38, 951-957.

Hadinegoro, S. R., Tumbelaka, A. R., & Satari, H. I. (2001). Pengobatan Cefixime pada Demam Tifoid Anak. Sari Pediatri, 2, 182-187

Rampengan, N. H. (2013). Antibiotik Terapi Demam Tifoid Tanpa Komplikasi pada Anak. Sari Pediatri, 5, 271-276.

Rampengan, T. H. (2008). Penyakit Infeksi Tropik pada Anak (2nded.). Jakarta:EGC.

Sidabutar, S., dan Satari, H. I. (2010). Pilihan Terapi Empiris Demam Tifoid pada Anak: Kloramfenikol atau Seftriakson? Sari Pediatri, 11, 434-439.

Santillán, R. M., García, G. R., Benavente I. H., & García, E. M. (2000). Efficacy of Cefixime in the Theraphy of Typhoid Fever. West Pharmacol, 43, 65-66.

Upadhyay, R., Nadkar, Y. M., Muruganathan, A., Tiwaskar, M., Amarapurkar, D., Banka, N. H., Mehta K. K., & Sathyaprakash, B. S. (2015). API Recommendations for the Management of Typhoid Fever. Journal of The Association of Physicians of India, 63, 77-95.