Management Of Minor Recurrent Aphthous Stomatitis With Normocytic Anemia as a Predisposing Factor : A Case Report
Keywords:
normocytic anemia;, recurrent aphthous stomatitisAbstract
Recurrent aphthous stomatitis (RAS) is an ulcerative lesion of the oral mucosa that often recurs and can be triggered by various factors, including stress and systemic conditions such as anemia. Hyperproliferative normocytic anemia, which can be caused by acute bleeding or hemolysis, contributes to the appearance of oral manifestations such as RAS, glossitis, angular cheilitis, and pale mucosa. This report presents a case of a 24-year-old female patient who experienced recurrent RAS related to stress and menstrual cycles, accompanied by indications of anemia. Management was carried out holistically with a combination of local therapy (topical corticosteroids and antiseptics), iron supplementation, and patient education regarding triggering factors and oral health care. The results show the importance of identifying and treating predisposing factors to reduce RAS recurrence and improve patient quality of life.
References
Mersil S, Andjani AMK. (2021). Gambaran Pengetahuan tentang Stomatitis Aftosa Rekuren (SAR) pada Mahasiswa Program Profesi FKG UPDM(B) Angkatan 2020. MDERJ. 1(1): 36-48.
Yonenda A, Prihantini MA. (2016). Management Of Recurrent Aphthous Stomatitis (RAS) Mayor In Buccal Mucosa. Proceedings Book Forkinas VI FKG UNEJ 14th-15th: 395-401.
Mersil S. (2021). Stomatitis sebagai Manifestasi Oral dari Anemia Defisiensi Zat Besi disertai Trombositosis. e-GiGi. 9(2): 181-187.
Yilmaz G., Shaikh Hira. (2020). Normochromic Normocytic Anemia. NCBI Bookshelf. A Service of the National Library of Medicine, National Institutes of Health. 1-12.
Little JW, Falace DA, Miller CS, Rhodus NL. (2017). Dental Management of the Medically Compromised Patient. Elsevier 9th ed. https://dl.konkur.in/post/Book/Dentistry/Little-and-Falace%27s-Dental-Management-of-the-Medically-Compromised-Patient-9th-Edition-%5Bkonkur.in%5D.pdf
Marinna A, Yusri M. (2022). Recurrent Oral Ulceration (ROU) In Microcytic Hypochromic Anemia (A Case Report). Medali Journal. 4(1): 71-82.
Puspita SRR, Wowor FM, Rambert IG. (2025). Gambaran Hemoglobin dan Indeks Eritrosit pada Remaja Putri. Jurnal Keperawatan. 13(1): 18-30.
Kementerian Kesehatan RI. (2018). Riset Kesehatan Dasar (Riskesdas).
McPherson RA, Pincus MR. (2017). Henry's Clinical Diagnosis and Management by Laboratory Methods. Elsevier 23rd ed. https://books.google.co.id/books?id=xAzhCwAAQBAJ&lpg=PP1&hl=id&pg=PR13#v=onepage&q&f=false
Mutiawati KV. (2018). Aspek Laboratorium pada Anemia Normositik Hiperproliferatif dan Hipoproliferatif. Jurnal Kedokteran Nanggroe Medika. 1(2): 71-80.
Weiss G, Goodnough LT. (2005). Anemia of Chronic Disease. N Engl J Med. 352(10) :1011-23.
Gazali NA, Hadi SW, Shafriani RN. (2024). Hubungan Hemoglobin dan Pola Menstruasi Terhadap Kejadian Anemia pada Mahasiswi di Asrama Putri Randik. Prosiding Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat. 2(28):2221-27.
Young NS. (2018). Aplastic Anemia. N Engl J Med. 379(17): 1643-1656
Greenberg MS, Glick M, Ship JA. (2015). Burket’s Oral Medicine. 12th ed
World Health Organization. (2011). Guideline: Intermittent Iron and Folic Acid Supplementation in Menstruating Women. https://www.who.int/publications/i/item/9789241502023
Tolkien Z, Stecher L, Mander AP, Pereira DI, Powell JJ. (2015). Ferrous Sulfate Supplementation Causes Significant Gastrointestinal Side-effects in Adults: a Systematic Review and Meta-analysis. PLoS ONE. 10(2): 1-20.
Cancelo-Hidalgo MJ, Castelo-Branco C, Palacios S, Haya Palazuelos J. Ciria Recasens M, Manasanch J, Perez-Edo L. (2013). Tolerability of Different Oral Iron Supplements: a Systematic Review. Current Medical Research and Opinion. 29(4): 291–303.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Ivan Hasan, Ahmad Ronal, Audiawati Surachmin, Nurfianti

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
This work is licensed under a CC Attribution-ShareAlike 4.0