Studi in silico Peran Gen IL10RB Homo sapiens (reseptor subunit beta interleukin 10) pada Infeksi Hepatitis B

Ndaru Andri Damayanti, Dwi Hilda Putri

Abstract


Inter  leukin,  IL-10  dikenal  sebagai  salah  satu  elemen  imun  yang  bersifat  anti  inflamasi memiliki peran penting di dalam sistem homeostasis. Gen IL-10RB yang termasuk kelompok sitokin kelas 2 merupakan lokus utama terhadap kejadian infeksi hepatitis B, yang diperlihatkan dengan adanya data single nucleotide polymorphisme, SNPs pada E47K. Studi in silico dilakukan untuk mengetahui mutasi dan perubahan fungsi dari protein IL-10RB yang mengalami mutasi terhadap kejadian infeksi oleh  virus hepatitis B.  Hasil analisis sikuen protein menunjukkan bahwa mutasi 2834167 tidak  merubah sifat  umum  maupun topologi protein IL-10RB terhadap kejadian infeksi hepatitis B. Hasil analisis struktur protein menunjukkan bahwa mutasi juga tidak merubah struktur sekunder maupun struktur Kristal D protein IL-10RB.


Keywords


in silico, gen, protein, IL-10RB, hepatitis B

Full Text:

PDF

References


Abbas AK, LA, and Pilai S. 2012. Celular and molecular immunology. Philadelpia, Elsevier/ Saunders., 2012

Cheng S, Lutfalla G, Uze G, Chumakov IM, Gardiner K. GART, SON, IFNAR and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mammalian Genome 4: 338-342,1993.

Cho O, Cheong JY, Jun KJ, Kim SS, Chwae YJ, Kim K, Park S, Cho SW. 2013. Relevance of interleukin-10RB to chronic hepatitis B virus infection and biological activities of interferon-k and interleukin-22. Hepatol Int

:111–118

Frodsham AJ, Zhang L, Dumpis U, Taib NA, Best S, Durham A, Hennig BJ, Hellier S, Knapp S, Wright M, Chiaramonte M, Bell JI, Graves M, Whittle HC, Thomas, Thursz HC, Hill AV. 2006. Class II cytokine receptor gene cluster is amajor locus for hepatitis B persistence, Proc. Natl. Acad. Sci. USA 103: 9148–9153.

Gong QM, Kong XF, Yang ZT, Xu J, Wang L, Li XL, Jin GD, Gao J, Zhang DH, Jian,g JH, Lu ZM, Zhang XX. 2009. Association study of IFNAR2 and IL10RB genes with the susceptibility and inter feron response in HBV infection. J Viral Hepat 16(9):674-80

Malefyt RW, Abrams J, Bennett B, Figdor CG, Vries JE. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes, J. Exp. Med. 174

–1220

Ott JJ, Stevens GA, Grogger J, Wiersma ST.2012. Global epidemiology of hepatitis B virus infection: new estimates of age- specific HBsAg seroprevalence and endemicity. J.Vaccine. 9;30(12):2212-9

Riskesdas 2017. Data dan Informasi Profil Kesehatan Indonesia. Kementerian Kesehatan RI.

Romporn S, Hirankarn N, Tangkijvanich P and Kimkong. 2013. I Association of IFNAR2 and IL10RB genes in chronic hepatitis B virus infection. Tissue Antigens, 82, 21–25

Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH, Kastelein R, Moore KW, Banchereau J. 1992. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes, Proc. Natl. Acad. Sci. USA 89 1890–1893.




DOI: http://dx.doi.org/10.33476/mkp.v10i2.727

Refbacks

  • There are currently no refbacks.


P-ISSN: 2085-5648

E-ISSN: 2655-2396