Hubungan Obesitas Sentral Dengan Gambaran Fatty Liver Pada USG Abdomen Di Poliklinik Bank Indonesia Bulan Agustus September 2017
Authors
-
Shahnaz Medina
-
Aris Wibudi
-
Oktania Sandra
Keywords:
fatty liver, obesitas sentral, indeks massa tubuh, lingkar pinggang, ultrasonografiAbstract
Obesitas sentral dikaitkan dengan perkembangan fatty liver dan peradangan hati. Indonesia memiliki prevalensi tertinggi untuk Non-Alcoholic Fatty Liver Disease (NAFLD) di Asia Tenggara (30%), prevalensi yang sama juga dilaporkan di Provinsi DKI Jakarta.Tujuan dari penelitian ini adalah mengetahui hubungan obesitas sentral dengan gambaran fatty liver pada USG abdomen di Poliklinik Bank Indonesia pada bulan Agustus-September 2017. Penelitian cross- sectional dilakukan pada bulan Agustus-September 2017. Kriteria inklusi adalah pasien obesitas sentral yang melakukan Ultrasonografi (USG) abdomen dengan fokus kelainan hati. Obesitas sentral dinilai dengan pengukuran antropometri yang terdiri dari indeks massa tubuh dan lingkar pinggang. Fatty Liver dikonfirmasi oleh USG abdomen yang berupa gambaran hiperekoik dan bright liver. Sampel diperoleh dengan menggunakan teknik fixed exposure sampling sehingga menghasilkan 42 subjek. Hubungan antara 2 variabel kategorik dianalisis dengan uji Chi-square menggunakan Statistical Product and Service Solution 21.0 (SPSS 21.0). Dari total 42 subjek, fatty liver ditemukan pada 31 subjek (73,8%). 26 subjek (61,9%) ditemukan memiliki obesitas sentral dan fatty liver. Ada hubungan yang signifikan antara obesitas sentral dan gambaran fatty liver pada USG abdomen (p: 0,003). Prevalence Odds Ratio (POR) menunjukkan peningkatan kemungkinan sebesar 9,1 kali lipat untuk subjek obesitas sentral menderita fatty liver. Terdapat hubungan antara obesitas sentral dengan fatty liver. Prevalence Odds Ratio (POR) yang menunjukkan peningkatan kemungkinan sebesar 9,1 kali lipat pada subjek obesitas sentral untuk menderita fatty liver daripada subjek tanpa obesitas sentral dapat memprediksi fatty liver pada individu dengan obesitas sentral.References
Agrawal R, Mishra S, Dixit VK, Rai S 2009. Association of non-alcoholic fatty liver disorder with obesity. Indian J Prev Soc Med. 2009;40:40-43.
Angulo P 2007. GI epidemiology: nonalcoholic fatty liver disease. Aliment. Pharmacol. Ther. 25, 883–889. doi:10.1111/j.1365-2036.2007.03246.x
Anon 2006. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society. Circulation, 114(7).
Amarapurkar DN, Hashimoto E, Lesmana LA, Sollano JD, Chen PJ, Goh KL 2007. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J. Gastroenterology. Hepatology. 22, 788–793. doi:10.1111/j.1440-1746.2007.05042.x
Arief MTQ 2008. Pengantar metodologi penelitian untuk ilmu kesehatan. Surakarta: UNS Press, pp: 53-76
ASEAN/UNICEF/WHO 2016. Regional Report on Nutrition Security in ASEAN,Volume 2. Bangkok;UNICEF.
Bae JC, Cho YK, Lee WY 2010. Impact of nonalcoholic fatty liver disease on insulin resistance in relation to HbA1c levels in non-diabetic subjects. Am J Gastroenterol. 2010;105(11):2389–2395. [PubMed]
Bayupurnama, Putut & Maduseno, S & Nurdjanah, S & Ratnasari, Neneng & Senorita, H & Asdie, Rizka & Mohd Hilmin, N & Ismail, A & Jamian, N. 2009. The Risk Factors Of Non-Alcoholic Fatty Liver Disease Prevalence In Obesity With Or Without Diabetes Mellitus. • The Internet Journal of Gastroenterology. 10.
Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S 2005. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology. 2005;42(1):44–52. doi: 10.1002/hep.20734. [PubMed] [Cross Ref]
Boer A 2010. Ultrasonografi; Pendahuluan, in: Rasad, Sjahriar (Eds.), Radiologi Diagnostik Edisi Kedua. Balai Penerbit FKUI, Jakarta, pp. 453–457.
Brea A 2005. Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis: A Case-Control Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(5), pp.1045–1050.
Caballeria L, Pera G, Auladell MA et al., 2010. Prevalence and factors associated with the presence of nonalcoholic fatty liver disease in an adult population in Spain. Eur J Gastroenterol Hepatol. 2010;22(1):24–32. 10.1097/MEG.0b013e32832fcdf0 [PubMed] [Cross Ref]
Chan D, Watts G, Ng T, Hua J, Song S and Barrett P 2006. Measurement of liver fat by magnetic resonance imaging: relationships with body fat distribution, insulin sensitivity and plasma lipids in healthy men. Diabetes, Obesity and Metabolism, 8(6), pp.698-702
Charismatika Syintia Dewi 2012. Hubungan Indeks Massa Tubuh Overweight Dengan Gambaran Fatty Liver Pada USG Abdomen di RSUD dr. Moewardi. UNIVERSITAS SEBELAS MARET.
Chitturi S, Farrell GC, George J 2004. Non-alcoholic steatohepatitis in the Asia-Pacific region: Future shock? J. Gastroenterol. Hepatol. 19, 368–374. doi:10.1111/j.1440-1746.2003.03252.x
Corey KE, Kaplan LM 2014. Obesity and liver disease. The epidemic of the twenty-first century. Clin. Liver Dis. 18, 1–18. doi:10.1016/j.cld.2013.09.019
Das K, Das K, Mukherjee PS, Ghosh A, Ghosh S, Mridha AR, Dhibas A et al., 2010. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology Volume 51, Issue 5: 1593-1602
Dhabi A, KJ B, TP P, PB T, MC S 2008. Non- Alcoholic Fatty Liver Disease (NAFLD). J. Indian Acad. Clin. Med. 9, 36–41.
Djokomoeltjanto R 2011. Endokrinologi pada usia lanjut. Dalam: Martono HH, Pranarka K (eds). Buku ajar Boedhi-Darmojo geriatric (ilmu kesehatan usia lanjut) edisi 4. Jakarta: Balai Penerbit FK UI, pp: 407-431
Dragan Micic, Goran Cvijovic 2008. Abdominal obesity and type 2 diabetes. European Endocrinology, 2008; 4:26-28; DOI: http://doi.org/10.17925/EE.2008.04.00.26
Everhart J and Bambha K 2010. Fatty liver: Think globally. Hepatology, 51(5), pp.1491-1493.
Fabbrini E, Sullivan S, Klein S 2010. Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications. Hepatology. doi:10.1002/hep.23280
FC KRUGER 2008. A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of selected candidate genes implicated in insulin resistance and fatty acid oxidation. Stellenbosch University.
Finucane MM, Stevens GA, Cowan M, et al., 2011. National, regional, and global trends in body mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet (London, England). 2011;377(9765):557-567. doi:10.1016/S0140-6736(10)62037-5.
Flegal K, Carroll M, Kit B and Ogden C 2012. Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010. JAMA, 307(5), p.491
Hall JE, Guyton AC 2012. Guyton and Hall Textbook of Medical Physiology, 11th ed, London: Elsevier Health Sciences.
Hamer OW, Aguirre Da, Casola G, Lavine JE, Woenckhaus M, Sirlin CB 2006. Fatty liver: imaging patterns and pitfalls. Radiographics 26, 1637–1653. doi:10.1148/rg.266065004.
Harrison SA, Day CP 2007. Recent advances in clinical practice: Benefits of lifestyle modification in NAFLD. Gut 56, 1760–1769. doi:10.1136/gut.2006.112094
Hasan I 2009. Perlemakan hati non alkoholik, in: Dalam:, AW, S., B, S., I, A., M, S., (eds, S.S. (Eds.), Buku Ajar Ilmu Penyakit Dalam Jilid I. Pusat Penerbitan Departemen Ilmu Penyakit Dalam,FKUI, Jakarta, pp. 695–701.
Hurjui DM, Ni?? O, Graur LI, Popescu D?, Mihalache L, Hu?ana?u CI, Graurx M 2012. The pathogenesis of non-alcoholic fatty liver disease is closely related to the metabolic syndrome components. Rom. J. Diabetes, Nutr. Metab. Dis. 19, 311–321. doi:10.2478/v10255-012-0037-x
Iljas M 2010. Ultrasonografi hati, in: Rasad, Sjahriar (Eds.), Radiologi Diagnostik Edisi Kedua. Balai Penerbit FKUI, Jakarta, pp. 467–479.
Iljas G, Budyatmoko B 2010. Perkembangan mutakhir pencitraan diagnostik (Diagnostic imaging), in: Rasad, Sjahriar (Eds.), Radiologi Diagnostik Edisi Kedua. Balai Penerbit FKUI, Jakarta, pp. 11-14
Joy D, Thava VR & Scott BB 2003. Diagnosis of fatty liver disease. European Journal of Gastroenterology & Hepatology, 15(5), pp.539–543.
Lee J, Chung DS, Kang JH, Yu BY 2012. Comparison of Visceral Fat and Liver Fat as Risk Factors of Metabolic Syndrome. J. Korean Med. Sci. 27, 184. doi:10.3346/jkms.2012.27.2.184
Lee SS, Park SH 2014. Radiologic evaluation of nonalcoholic fatty liver disease. World J. Gastroenterol. 20, 7392–7402. doi:10.3748/wjg.v20.i23.7392
Lee S, Yang S, Lee T, Yeh H, Tung C, Chang C 2017. The association of non-alcoholic fatty liver disease with body mass index and waist circumference in a Chinese population 1–7. doi:10.14800/janhm.1483
Manco M, Bottazzo G, DeVito R, Marcellini M, Mingrone G, Nobili V 2008. Nonalcoholic fatty liver disease in children. Journal of the American College of Nutrition, Vol. 27, No. 6: 667–676
Miles JM, Jensen MD 2005. Counterpoint: visceral adiposity is not causally related to insulin resistance. Diabetes Care 2005;28:2326–2328.
Nguyen NT, Magno CP, Lane KT, Hinojosa MW, Lane JS 2008. Association of Hypertension, Diabetes, Dyslipidemia, and Metabolic Syndrome with Obesity: Findings from the National Health and Nutrition Examination Survey, 1999 to 2004. J. Am. Coll. Surg. 207, 928–934. doi:10.1016/j.jamcollsurg.2008.08.022.
NICE 2006. Working with people to prevent and manage overweight and obesity: the issues [WWW Document]. accessed 7.14.17 www.nice.org.uk/guidance/cg43
Nielsen S, Guo Z, Johnson CM, Hensrud DD, Jensen MD 2004. Splanchnic lipolysis in human obesity. J. Clin. Invest. 113, 1582–1588. doi:10.1172/JCI200421047.
Pang Q 2015. Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index. World J. Gastroenterol. 21, 1650. doi:10.3748/wjg.v21.i5.1650
Patel PR 2007. Lecture notes radiologi edisi kedua. Erlangga, Jakarta. pp:135-157
Popkin BM, Slining MM 2013. New dynamics in global obesity facing low- and middle-income countries. Obes Rev 2013;14(Suppl.2):11e20. doi:http://dx.doi.org/10.1111/obr.12102. Epub November 2013.
Rachmi CN, Li M, Baur LA 2017. Overweight and obesity in Indonesia : prevalence and risk factors d a literature review 7. doi:10.1016/j.puhe.2017.02.002
Riwidikdo H 2009. Statistik Kesehatan. Yogyakarta: Mitra Cendekia Press, pp: 102-124
Roemling C, Qaim M 2012. Obesity trends and deterinants in Indonesia. Appetite 2012;58(3);1005e13. doi:http://dx.doi.org/ 10.1016/j.appet.2012.02.053. PubMed PMID: 22402303
Sass DA, Chang P, Chopra KB 2005. Nonalcoholic fatty liver disease: A clinical review. Dig. Dis. Sci. 50, 171–180. doi:10.1007/s10620-005-1267-z
Targher G, Bertolini L, Scala L, Zoppini G, Zenari L and Falezza G 2005. Non-alcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in non-diabetic men. Role of visceral adipose tissue. Diabetic Medicine, 22(10), pp.1354-1358
Thamer C, Machann J, Stefan N, Haap M, Schäfer S, Brenner S, Kantartzis K, Claussen C, Schick F, Haring H, Fritsche A 2007. High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention. Obesity (Silver Spring). 15, 531–538. doi:10.1038/oby.2007.568.
Tiniakos MB Vos and EM Brunt 2010. “Nonalcoholic fatty liver disease,” Review of Pathology, vol. 5, pp. 145–171, 2010.
Torruellas C, French SW, Medici V 2014. Diagnosis of alcoholic liver disease. World Journal of Gastroenterology : WJG. 2014;20(33):11684-11699. doi:10.3748/wjg.v20.i33.11684.
Trihatmowijoyo BM, Nusi AI 2009. Key fatty liver dan transplantasi liver. Diakses Agustus 2017 www.scribd.com/doc/38683046/final-FT-1
WHO 2008. Waist circumference and waist–hip ratio: report of a WHO expert consultation, Geneva, 8–11 December 2008.
Wang Y, McPherson K, Marsh T, Gortmaker S, Brown M 2011. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378 815–825. doi:doi:10.1016/s0140-6736(11)60814-3
Wang H, Wang J, Liu MM, Wang D, Liu YQ, Zhao Y, Huang M, Liu Y, Sun J, Dong GH 2012. Epidemiology of general obesity, abdominal obesity and related risk factors in urban adults from 33 communities of Northeast China: the CHPSNE study. BMC Public Health 12, 967. doi:10.1186/1471-2458-12-967
WHO Media Centre 2017. Obesity and Overweight, Diakses 12 Februari 2018 http://www.who.int/mediacentre/factsheets/fs311/en/
WHO western pacific region 2000. The Asia-Pacific perspective: Redefining obesity and its treatment, IASO inter. ed. international obesity taskforce.
Zhang 2010. Key pengontrolan ilmiah penyakit perlemakan hati. Diakses Februari 2018 http://indonesian.cri.cn/381/2009/06/28/1s98435.htm
Zelber-Sagi S, Nitzan-Kaluski D, Halpern Z, Oren R 2006. Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int. 26, 856–863. doi:10.1111/j.1478-3231.2006.01311.x
