Relationship Between TNF-238G>A Polymorphism and Predisposition to Pulmonary Tuberculois Infection in The Indonesian Population (A Pilot Study)

Syurlia Putri, Sausan Rasmiyyah, Evita Amalia Huskany, Intan Razari, Britanto Dani Wicaksono, Rika Yuliwulandari

Abstract


Previous studies suggested that genetic factors exerted huge influence in susceptibility to Tuberculosis. Tumor Necrosis Factor Alpha (TNF-a), which is encoded by the TNF gene, play a role on pulmonary macrophage function in isolating and controlling Mycobacterium tuberculosis infection. Polymorphisms on the promoter region of the TNF gene have been predicted to affect its transcriptional activity. Therefore, these polymorphisms are an excellent candidate to further study the role of TNF-a in susceptibility to Tuberculosis. 100 pulmonary tuberculosis patients (case) and 100 healthy individuals (controls) were recruited for this pilot study. DNA samples from cases and controls were genotyped for the TNF -238G>A SNP (rs361525) using LightSNip genotyping assay. Our results showed no significant difference in the distribution of TNF -238 genotypes in case and control subjects (P = 0.4335). Further investigation on TNF -238 allele frequencies between case and control studies also yields no significant difference (P=1.000; OR=1.000; %95CI [0.246597 – 4.055200]) which may suggest that there are no association with predisposition to Tuberculosis infection. In conclusion, this pilot study showed that the TNF -238G>A SNP is not associated with susceptibility to Tuberculosis.


Keywords


Tuberculosis; Susceptibility; Single Nucleotide Polymorphism; Tumor Necrosis Factor

Full Text:

Download File

References


Abraham LJ and Kroeger KM 1999. Impact of the-308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease. J Leukocyte Biol 66 (4): 562-6.

Amirzargar AA, Rezaei N, Jabbari H, Danesh A-A, Khosravi F, Hajabdolbaghi M, Yalda A and Nikbin B 2006. Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis. Eur Cytokine Netw 17 (2): 84-9.

Anoosheh S, Farnia P and Kargar M 2011. Association between TNF-Alpha (-857) Gene Polymorphism and Susceptibility to Tuberculosis. Iranian Red Crescent Medical Journal 13 (4): 243-8.

Ates O, Musellim B, Ongen G and Topal-Sarikaya A 2008. Interleukin-10 and tumor necrosis factor-alpha gene polymorphisms in tuberculosis. J Clin Immunol 28 (3): 232-6.

Baena A, Leung JY, Sullivan AD, Landires I, Vasquez-Luna N, Quinones-Berrocal J, Fraser PA, Uko GP, Delgado JC, Clavijo OP, Thim S, Meshnick SR, Nyirenda T, Yunis EJ and Goldfeld AE 2002. TNF-[alpha] promoter single nucleotide polymorphisms are markers of human ancestry. Genes Immun 3 (8): 482-7.

Bayley JP, Ottenhoff TH and Verweij CL 2004. Is there a future for TNF promoter polymorphisms? Genes Immun 5 (5): 315-29.

Bellamy R 1998. Genetic susceptibility to tuberculosis in human populations. Thorax 53 (7): 588-93.

Brinkman BM, Zuijdeest D, Kaijzel EL, Breedveld FC and Verweij CL 1995. Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation. J Inflammation 46 (1): 32-41.

Comstock GW 1978. Tuberculosis in twins: a re-analysis of the Prophit survey. The American review of respiratory disease 117 (4): 621-4.

Correa PA, Gomez LM, Cadena J and Anaya JM 2005. Autoimmunity and tuberculosis. Opposite association with TNF polymorphism. J Rheumatol 32 (2): 219-24.

Delgado JC, Baena A, Thim S and Goldfeld AE 2002. Ethnic-specific genetic associations with pulmonary tuberculosis. J Infect Dis 186 (10): 1463-8.

Ding S, Jiang T, He J, Qin B, Lin S and Li L 2012. Tagging single nucleotide polymorphisms in the IRF1 and IRF8 genes and tuberculosis susceptibility. PLoS One 7 (8): e42104.

Elahi MM, Asotra K, Matata BM and Mastana SS 2009. Tumor necrosis factor alpha −308 gene locus promoter polymorphism: An analysis of association with health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792 (3): 163-72.

Flesch IE and Kaufmann SH 1990. Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor. Infect Immun 58 (8): 2675-7.

Flori L, Delahaye NF, Iraqi FA, Hernandez-Valladares M, Fumoux F and Rihet P 2005. TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso. Genes Immun 6 (6): 472-80.

Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreiber R, Mak TW and Bloom BR 1995. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2 (6): 561-72.

Goldfeld AE, Doyle C and Maniatis T 1990. Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide. Proc Natl Acad Sci U S A 87 (24): 9769-73.

Hatin W, Nur-Shafawati A, Etemad A, Jin W, Qin P, Xu S, Jin L, Tan S-G, Limprasert P, Feisal M, Rizman-Idid M, Zilfalil B and Consortium THP-AS 2014. A genome wide pattern of population structure and admixture in peninsular Malaysia Malays. The HUGO Journal 8 (1): 5.

Henao MI, Montes C, Paris SC and Garcia LF 2006. Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis. Tuberculosis (Edinb) 86 (1): 11-9.

Higuchi T, Seki N, Kamizono S, Yamada A, Kimura A, Kato H and Itoh K 1998. Polymorphism of the 5'-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese. Tissue Antigens 51 (6): 605-12.

Höhler T, Kruger A, Gerken G, Schneider PM, Meyer Zum Büschenfelde KH and Rittner C 1998. A tumour necrosis factor-alpha (TNF-α) promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol 111 (3): 579-82.

Huizinga TW, Westendorp RG, Bollen EL, Keijsers V, Brinkman BM, Langermans JA, Breedveld FC, Verweij CL, van de Gaer L, Dams L, Crusius JB, Garcia-Gonzalez A, van Oosten BW, Polman CH and Pena AS 1997. TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol 72 (2): 149-53.

Kaijzel EL, van Krugten MV, Brinkman BM, Huizinga TW, van der Straaten T, Hazes JM, Ziegler-Heitbrock HW, Nedospasov SA, Breedveld FC and Verweij CL 1998. Functional analysis of a human tumor necrosis factor alpha (TNF-alpha) promoter polymorphism related to joint damage in rheumatoid arthritis. Mol Med 4 (11): 724-33.

Kallmann FJ and Reisner D 1943. Twin studies on the significance of genetic factors in tuberculosis. Am Rev Tuberc 47: 549-74.

Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, Siegel JN and Braun MM 2001. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 345 (15): 1098-104.

Kim HS, Park MH, Song EY, Park H, Kwon SY, Han SK and Shim YS 2005. Association of HLA-DR and HLA-DQ genes with susceptibility to pulmonary tuberculosis in Koreans: preliminary evidence of associations with drug resistance, disease severity, and disease recurrence. Hum Immunol 66 (10): 1074-81.

Kleinnijenhuis J, Oosting M, Joosten LA, Netea MG and Van Crevel R 2011. Innate immune recognition of Mycobacterium tuberculosis. Clin Dev Immunol 2011.

Knight JC, Keating BJ, Rockett KA and Kwiatkowski DP 2003. In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nat Genet 33 (4): 469-75.

Kobayashi K, Yuliwulandari R, Yanai H, Naka I, Lien LT, Hang NT, Hijikata M, Keicho N and Tokunaga K 2012. Association of TLR polymorphisms with development of tuberculosis in Indonesian females. Tissue Antigens 79 (3): 190-7.

Kroeger KM, Carville KS and Abraham LJ 1997. The− 308 tumor necrosis factor-α promoter polymorphism effects transcription. Mol Immunol 34 (5): 391-9.

Lin PL, Plessner HL, Voitenok NN and Flynn JL 2007. Tumor necrosis factor and tuberculosis. J Investig Dermatol Symp Proc 12 (1): 22-5.

Mekinian A, Tamouza R, Pavy S, Gestermann N, Ittah M, Mariette X and Miceli-Richard C 2011. Functional study of TNF-α promoter polymorphisms: literature review and meta-analysis. Eur Cytokine Netw 22 (2): 88-102.

Mohan VP, Scanga CA, Yu K, Scott HM, Tanaka KE, Tsang E, Tsai MM, Flynn JL and Chan J 2001. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect Immun 69 (3): 1847-55.

Morales-Garcia G, Falfan-Valencia R, Garcia-Ramirez RA, Camarena A, Ramirez-Venegas A, Castillejos-Lopez M, Perez-Rodriguez M, Gonzalez-Bonilla C, Grajales-Muniz C, Borja-Aburto V and Mejia-Arangure JM 2012. Pandemic influenza A/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCL polymorphisms in Mexican population: a case-control study. BMC Infect Dis 12: 299.

Motulsky AG 1989. Metabolic polymorphisms and the role of infectious diseases in human evolution. Hum Biol: 835-69.

Murray CJ, Styblo K and Rouillon A 1990. Tuberculosis in developing countries: burden, intervention and cost. Bulletin of International Union against Tuberculosis and Lung Disease 65 (1): 6-24.

Oliveira MMd, Silva JCSd, Costa JF, Amim LH, Loredo CCS, Melo H, Queiroz LF, Mello FCQ, Lapa e Silva JR, Kritski AL and Santos AR 2004. Distribuição de Polimorfismos de Base única (SNPs) no gene de TNF-a (-238/-308) entre pacientes com TB e outras pneumopatias: marcadores genéticos de susceptibilidade a ocorrência de TB? Jornal Brasileiro de Pneumologia 30: 371-7.

Pociot F, D'Alfonso S, Compasso S, Scorza R and Richiardi PM 1995. Functional Analysis of a New Polymorphism in the Human TNF α Gene Promoter. Scand J Immunol 42 (4): 501-4.

Selvaraj P, Sriram U, Mathan Kurian S, Reetha AM and Narayanan PR 2001. Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis: haplotype analysis with HLA-A, B and DR genes. Tuberculosis (Edinb) 81 (5-6): 335-41.

Skoog T, van't Hooft FM, Kallin B, Nilsson J, Eriksson P and Hamsten A 1999. A common polymorphism in the promoter region of TNF-alpha gene determining the serum TNF-alpha concentration. Atherosclerosis 144: 121.

Stead WW, Senner JW, Reddick WT and Lofgren JP 1990. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. New Engl J Med 322 (7): 422-7.

Uglialoro AM, Turbay D, Pesavento PA, Delgado JC, McKenzie FE, Gribben JG, Hartl D, Yunis EJ and Goldfeld AE 1998. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-α gene promoter. Tissue Antigens 52 (4): 359-67.

Vannberg FO, Chapman SJ, Khor CC, Tosh K, Floyd S, Jackson-Sillah D, Crampin A, Sichali L, Bah B, Gustafson P, Aaby P, McAdam KP, Bah-Sow O, Lienhardt C, Sirugo G, Fine P and Hill AV 2008. CD209 genetic polymorphism and tuberculosis disease. PLoS One 3 (1): e1388.

Vejbaesya S, Chierakul N, Luangtrakool P and Sermduangprateep C 2007. NRAMP1 and TNF-α polymorphisms and susceptibility to tuberculosis in Thais. Respirology 12 (2): 202-6.

WHO 2014. Global Tuberculosis Report 2014. World Health Organization.

Wilson A, Symons J, McDowell T, Di Giovine F and Duff G 1994. Effects of a tumor necrosis factor (TNF-alpha) promoter base transition on transcriptional activity. Br J Rheumatol 33 (suppl 1): 89.

Yea SS, Yang YI, Jang WH, Lee YJ, Bae HS and Paik KH 2001. Association between TNF-alpha promoter polymorphism and Helicobacter pylori cagA subtype infection. J Clin Pathol 54 (9): 703-6.




DOI: https://doi.org/10.33476/jky.v23i1.112

Refbacks

  • There are currently no refbacks.


Copyright (c) 2015 Jurnal Kedokteran YARSI

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

__________________________________________________________________________________________

Copyright of YARSI Medical Journal.

Powered by OJS.

Creative Commons License

This work is licensed under a Creative Commons Attribution- NonCommercial 4.0 International License.